T Lymphocytes pp 187-194 | Cite as

Immunosuppression by MHC Class II Blockade

  • Luciano Adorini
Part of the NATO ASI Series book series (NSSA, volume 233)


Antigen processing and presentation is a complex set of events leading to the activation of specific T cells by a binary ligand formed by antigenic peptides bound to major histocompatibility complex (MHC)-encoded molecules (1, 2).


Experimental Autoimmune Encephalomyelitis Antigenic Peptide Clonal Dominance Competitor Peptide Cell Receptor Ligand 
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  1. 1.
    Bjorkman, P.J., M.A. Saper, B. Samraoui, W.S. Bennett, J.L. Strominger, and D.C. Wiley. 1987. Structure of the human class I histocompatibiliy antigen, HLA-A2. Nature 329:506.PubMedCrossRefGoogle Scholar
  2. 2.
    Brown, J.H., T. Jardetzky, M.A. Saper, B. Samraoui, P.J. Bjorkman, and D.C. Wiley. 1988. A hypothetical model of the foreign antigen binding site of class II histocompatibility molecules. Nature 332:845.PubMedCrossRefGoogle Scholar
  3. 3.
    Moller, G. (ed.). 1988. Antigen processing. Immunol. Rev. 106:1–157.Google Scholar
  4. 4.
    Adorini, L. 1990. The presentation of antigen by MHC class II molecules. Year Immunol. 6:21.Google Scholar
  5. 5.
    Koshland, D.E., Jr. (ed.) 1990. Tolererance in the im- mune system. Science 248:1335.Google Scholar
  6. 6.
    Nepom G.T. 1988. Immunogenetics of HLA-associated dis- eases. Concepts Immunopath. 5:80.Google Scholar
  7. 7.
    Todd J.A., H. Acha-Orbea, J.I. Bell, N. Chao, Z. Fronek, C.O. Jacob, M. McDermott, A.A. Sinha, L. Timmermann, L. Steinman, and H.O. McDevitt. 1988. A molecular basis for MHC Class II-associated autoimmunity. Science 240:1003.PubMedCrossRefGoogle Scholar
  8. 8.
    Adorini, L., V. Barnaba, C. Bona, F. Celada, A. Lan- zavecchia, E. Sercarz, N. Suciu-Foca, and H. Wekerle. 1990. New perspectives on immunointervention in autoimmune diseases. Immunol. Today 11:383.PubMedCrossRefGoogle Scholar
  9. 9.
    Adorini, L., and Z.A. Nagy. 1990. Peptide competition for antigen presentation. Immunol. Today 11:21.PubMedCrossRefGoogle Scholar
  10. 10.
    Janeway, C. 1989. Immunotherapy by peptides. Nature 341:482.PubMedCrossRefGoogle Scholar
  11. 11.
    Adorini, L., S. Muller, F. Cardinaux, P.V. Lehmann, F. Falcioni, and Z.A. Nagy. 1988. In vivo competition between self peptides and foreign antigens in T cell activation. Nature 334:623.PubMedCrossRefGoogle Scholar
  12. 12.
    Adorini, L., E. Appella, G. Doria, and Z.A. Nagy. 1988. Mechanisms influencing the immunodominance of T cell determinants. J. Exp. Med. 168:2091.PubMedCrossRefGoogle Scholar
  13. 13.
    Wraith D.C., D.E. Smilek, D.J. Mitchell, L. Steinman, and H.O. McDevitt. 1989. Antigen recognition in autoimmune encephalomyelitis and the potential for peptide-mediated immunotherapy. Cell 59:247.PubMedCrossRefGoogle Scholar
  14. 14.
    Sakai, K., S.S. Zamvil, D.J. Mitchell, S. Hodgkinson, J.B. Rothbard, and L. Steinman. 1989. Prevention of experimental encephalomyelitis with peptides that block interaction of T cells with major histocompatibility complex protein. Proc. Natl. Acad. Sci. USA 86:9470.PubMedCrossRefGoogle Scholar
  15. 15.
    Lamont A.G., A. Sette, R. Fujinami, S.M. Colon, C. Miles, and H.M. Grey. 1990. Inhibition of experimental autoimmune encephalomyelitis induction in SJL/J mice by using a peptide with high affinity for I-As molecules. J. Immunol. 145:1687.PubMedGoogle Scholar
  16. 16.
    Evavold, B.D., and P.M. Allen. 1991. Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand. Science 252:1308.PubMedCrossRefGoogle Scholar
  17. 16.
    Evavold, B.D., and P.M. Allen. 1991. Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand. Science 252:1308.PubMedCrossRefGoogle Scholar
  18. 17.
    Smilek, D.E., D.C. Wright, S. Hodgkinson, S. Dwivedy, L. Steinman, and H.O. McDevitt. A single amino acid change in a myelin basic protein peptide confers the capacity to prevent rather than induce experimental autoimmune encephalomyelitis. Proc. natl. Acad Sci USA, in press.Google Scholar
  19. 18.
    Zamvil, S.S., D.J. Mitchell, N.E. Lee, A.C. Moore, K. Kitamura, L. Steinman, and J.B. Rothbard. 1986. T cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis. Nature 324:258.PubMedCrossRefGoogle Scholar
  20. 19.
    Smilek, D.E., B.L. Lock, and H.O. McDevitt. 1990. Antigenic recognition and peptide-mediated immunotherapy in autoimmune disease. Immunol. Rev. 118:37.PubMedCrossRefGoogle Scholar
  21. 20.
    Muller, S., L. Adorini, A. Juretic, and Z.A. Nagy. 1990. Selective in vivo inhibition of T cell activation by class II MHC-binding peptides administered in soluble form. J. Immunol. 145:4006.PubMedGoogle Scholar
  22. 21.
    Adorini, L., Moreno, J., Momburg, F., Hammerling, G.J., Guery, J-C., Valli, A., and Fuchs S. 1991. Exogenous peptides compete for the presentation of endogenous antigens to major histocompatibility class II-restricted T cells. J. Exp. Med 174:0000.CrossRefGoogle Scholar
  23. 22.
    Gammon, G., H.M. Geysen, R.J. Apple, E. Pickett, M. Palmer, A. Ametani, and E.E. Sercarz. 1991. T cell determinant structure: cores and determinant envelopes in three mouse majoe histocompatibility complex haplotypes. J. Exp. Med. 173:609.PubMedCrossRefGoogle Scholar
  24. 23.
    Adorini, L. (ed.) 1990. The molecular basis of antigen presentation to T lymphocytes: novel possibilities for immunointervention. Intern. Rev. Immunol. 6:1–88.Google Scholar
  25. 24.
    Gefter, M.L. (ed.) 1991. Major Histocompatibility Complex and peptides in immunotherapy. Sem. Immunol.3:193–255.Google Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Luciano Adorini
    • 1
  1. 1.Preclinical Research Sandoz Pharma Ltd.BaselSwitzerland

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