Skip to main content
SpringerLink
Log in

Structure of the TCR-Ag-MHC Complex

  • Chapter
T Lymphocytes

Part of the book series: NATO ASI Series ((NSSA,volume 233))

Abstract

T cells recognize foreign antigen via a tri-molecular complex composed of the T cell receptor (TCR), an antigenic peptide (Ag), and a molecule encoded by the major histocompatibility complex (MHC). Much effort has been devoted to solving the crystal structure of the TCR-Ag-MHC complex, but this formidable feat has so far been unsuccessful. In the meantime, several models of the interacting triad have been proposed (1–3) on the basis of the marked sequence homology between TCRs and immunoglobulins and on the known structure of MHC class I molecules surmised from X-ray crystallographic studies (4,5).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Davis, M.M., and Bjorkman, P.J. (1988) Nature 334,395–402.

    Article  PubMed  CAS  Google Scholar 

  2. Chothia, C., Boswell, D.R., and Lesk, A.M. (1988) EMBO J; 7,3745–3755.

    PubMed  CAS  Google Scholar 

  3. Claverie, J.M., Prochnicka-Chalufour, A., and Bougueleret, L. (1989) Immunol. Today, 10,10–13.

    Article  PubMed  CAS  Google Scholar 

  4. Bjorkman, P.J., Saper, M.A., Samraoui, B., Bennett, W.S., Srominger, J.L., and Wiley, D.C. (1987a) Nature 329,506–512.

    Article  CAS  Google Scholar 

  5. Bjorkman, P.J., Saper, M.A., Samraoui, B., Bennett, W.S., Strominger, J.L., and Wiley, D.C. (1987b) Nature, 329,512–518.

    Article  CAS  Google Scholar 

  6. Sorger, S.B., Hedrick, S.M., Fink, P.J., Bookman, M.A., and Matis. L.A. (1987) J. Exp. Med. 165,279–301.

    Article  PubMed  CAS  Google Scholar 

  7. Acha-Orbea, H., Mitchell, D.J., Timmermann, L., Wraith, D.C., Tausch, G.S., Waldor, M.K., Zamvil, S.C., McDevitt, H.O., and Steinman, L. (1988) Cell 54,263–273.

    Article  PubMed  CAS  Google Scholar 

  8. Urban, J.L., Kumar, V., Kono, D.H., Gomez, C., Horvath, S.J., Clayton, J., Ando, D.G., Sercarz, E.E., and Hood, L. (1988) Cell 54,577–592.

    Article  PubMed  CAS  Google Scholar 

  9. Tan, K-N., Datlof, B.M., Gilmore, J.A., Kronman, A.C., Lee, J.H., Maxam, A.M., and Rao, A. (1988) Cell 54,247–261.

    Article  PubMed  CAS  Google Scholar 

  10. Lai, M-Z., Jang, Y-J., Chen, L-K., and Gefter, M.L. (1990) J. Immunol. 144,4851–4856.

    PubMed  CAS  Google Scholar 

  11. Danska, J.S., Livingstone, A.M., Paragas, V., Ishihara, T., and Fathman, C.G. (1990) J. Exp. Med.172,27–33.

    Article  PubMed  CAS  Google Scholar 

  12. Aebischer, T., Oehen, S., and Hengartner, H. (1990) Eur. J. Immunol. 20,523–531.

    Article  PubMed  CAS  Google Scholar 

  13. Yanagi, Y., Maekawa, R., Cook, T., Kanagawa, O., Michael, B., Oldstone, A. (1990). J. Virology 64,5919–5926.

    PubMed  CAS  Google Scholar 

  14. Koseki, H., Imai, K., Ichikawa, T., Hayata, I., and Taniguchi, M. (1989). Internat. Immunol. 1,557–564.

    Article  CAS  Google Scholar 

  15. Wither, J., Pawling, J., Phillips, L., Delovitch, T., and Hozumi, N. (1991) J. Immunol. 146,3513–3522.

    PubMed  CAS  Google Scholar 

  16. Kempkes, M., Palmer, E., Martin, S., von Bonin, A., Eichmann, K., Ortmann, B., and Weltzien, H.U. (1991) J. Immunol. 147,2467–2473.

    PubMed  CAS  Google Scholar 

  17. Brändle, D., Bürki, K., Wallace, V.A., Hoffmann Rohrer, U., Mak, T.W., Malissen, B., Hengartner, H., and Pircher, H. (1991) Eur. J. Immunol. 21,2195–2202.

    Article  PubMed  Google Scholar 

  18. Jorgensen, J.L., Esser, U., Fazekas de Groth, B., Reay, P.A., and Davis, M.M. (1991) Nature, in press.

    Google Scholar 

  19. Dellabona, P., Peccoud, J., Kappler, J., Marrack, P., Benoist, C., Mathis, D. (1990) Cell 62,1115–1121.

    Article  PubMed  CAS  Google Scholar 

  20. Peccoud, J., Dellabona, P., Allen, P., Benoist, C., and Mathis, D. (1990) EMBO J. 9,4215–4223.

    PubMed  CAS  Google Scholar 

  21. Wei, B-W., Gervois, N., Mer, G., Adorini, L., Benoist, C., Mathis, D. (1991) Int. Immunol. 3,833–837.

    Article  PubMed  CAS  Google Scholar 

  22. Brown, J.H., Jardetzky, T., Saper, M.A., Samraoui, B., Bjorkman, P.J., and Wiley, D.C. (1988) Nature 332,845–850.

    Article  PubMed  CAS  Google Scholar 

  23. Rupp, F., Acha-Orbea, H., Hengartner, H., Zinkernagel, R., and Joho, R. (1985) Nature 315,425–427.

    Article  PubMed  CAS  Google Scholar 

  24. Perkins, D.L., Lai, Ming-Zing, Smith, J.A., and Gefter, M.L. (1989) J. Exp. Med. 170,279–283.

    Article  PubMed  CAS  Google Scholar 

  25. Gorga, J.C., Dong, A., Manning, M.C., Woody, R.W., Caughey, W.S., and Strominger, J.L. (1989) Proc. Natl. Acad. Sci USA 86,2321–2325.

    Article  PubMed  CAS  Google Scholar 

  26. Lorenz, R.G., Tyler, A.N., and Allen, P.M. (1989). J. Exp. Med. 170,203–207.

    Article  PubMed  CAS  Google Scholar 

  27. Warren, A.P., Paschedag, I., Benoist, C., Peccoud, J., Mathis, D. and Thomas, D.B. (1990) EMBO J. 9,3849–3856.

    PubMed  CAS  Google Scholar 

  28. Brett, S.J., McKean, D., York-Jolley, J., and Berzofsky, J.A. (1989) Int. Immunol. 1,130–140

    Article  PubMed  CAS  Google Scholar 

  29. Krieger, J.I., Karr, R.W., Grey, H.M., Yu, W-Y., O’Sullivan, D., Batovsky, L., Zheng, Z-L., Colon, S.M., Gaeta, F.C.A., Sidney, J., Albertson, M., del Guercio, M-F., Chesnut, R.W., and Sette, A. (1991) J. Immunol. 146,2331–2340.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS et U/184 INSERM, Institut de Chimie Bilogique Faculté de Médecine, Strasbourg, France

    Nadine Gervois, Bing-Yuan Wei, Paolo Dellabona, Jean Peccoud, Christophe Benoist & Diane Mathis

Authors
  1. Nadine Gervois
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Bing-Yuan Wei
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Paolo Dellabona
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jean Peccoud
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Christophe Benoist
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Diane Mathis
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. The Hospital for Joint Diseases, New York University, New York, New York, USA

    Franco Celada

  2. Columbia University, New York, New York, USA

    Benvenuto Pernis

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer Science+Business Media New York

About this chapter

Cite this chapter

Gervois, N., Wei, BY., Dellabona, P., Peccoud, J., Benoist, C., Mathis, D. (1992). Structure of the TCR-Ag-MHC Complex. In: Celada, F., Pernis, B. (eds) T Lymphocytes. NATO ASI Series, vol 233. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3054-1_2

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-3054-1_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6332-3

  • Online ISBN: 978-1-4615-3054-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation