Abstract
The development of mature T-cell subsets can be divided into several critical steps beginning in the thymus and continuing in peripheral lymphoid tissues. Ligation of the surface αβ receptor on CD4+8+ cells can result in survival (positive selection) (Benoist & Mathis, 1989) and further maturation along either the CD4/helper pathway or CD8/cytotoxic pathway. Clones that escape intrathymic deletion following TCR ligation by MHC/self peptide complexes on dendritic cells may migrate to the periphery, where subsequent TCR ligation can result in clonal energy or in expression of specialized T-cell function (Schwartz, R. 1990; Whiteley et al, 1990). In the case of CD4+ TH cells, ligation of the TCR may lead to alternative functional phenotypes associated with different patterns of cytokine gene expression The TCR-linked signalling events responsible for acquisition of these successive alternative phenotypes during the development of T-cells are not understood.
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Liu, H., Cantor, H. (1992). Alternative Pathways of Signal Transduction after Ligation of the TCR by Bacterial Superantigen. In: Celada, F., Pernis, B. (eds) T Lymphocytes. NATO ASI Series, vol 233. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3054-1_18
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DOI: https://doi.org/10.1007/978-1-4615-3054-1_18
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