Abstract
It is well known that the cells of higher organisms are able to excrete unwanted foreign chemicals (pesticides, herbicides, aromatic amines used in the dye industries, etc.) after metabolic conversion. An important role in this process is performed by reduced glutathione (GSH) which is present at high concentrations (2mM) in all living cells. In human cells, such as erythrocytes, GSH can be conjugate to a number of electrophilic compounds by the catalytic reaction of glutathione S-transferase (GST).1–3 The intracellular glutathione S-conjugate is excreted from the erythrocytes by an ATP requiring transport system.4,5 This process plays an important role as a detoxification mechanism that protects the red blood cells (RBCs) as well as other tissue cells from injuries by xenobiotics.
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Fazi, A., Mancini, U., Piatti, E., Accorsi, A., Magnani, M. (1992). Xenobiotic Detoxification by GSH-Loaded Erythrocytes. In: Magnani, M., DeLoach, J.R. (eds) The Use of Resealed Erythrocytes as Carriers and Bioreactors. Advances in Experimental Medicine and Biology, vol 326. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3030-5_24
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DOI: https://doi.org/10.1007/978-1-4615-3030-5_24
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