Abstract
The most important role in ethanol metabolism is played in mammals by the liver. It has been calculated that this organ oxidizes about 80% of the ingested ethanol,while the remainder is metabolized at other body sites or it is excreted in breath, urine and sweat. Ethanol is oxidized to acetaldehyde (Ach) in liver by three different enzymatic pathways: alcohol dehydrogenase (ADH), the cytochrome P-450 microsomal ethanol oxidizing system (MEOS) and the catalase pathways (Fig.1). A non enzymatic ethanol oxidizing system has also been proposed.1 All these pathways have been recently reviewed in detail by Kennedy and Tipton.2 In contrast to ADH which is only slightly inducible3, the MEOS specifically increases its activity following chronic ethanol consumption.4,5
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Ninfali, P., Rossi, L., Baronciani, L., Ropars, C., Magnani, M. (1992). Acetaldehyde Oxidation by Aldehyde Dehydrogenase Loaded Erythrocytes. In: Magnani, M., DeLoach, J.R. (eds) The Use of Resealed Erythrocytes as Carriers and Bioreactors. Advances in Experimental Medicine and Biology, vol 326. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3030-5_20
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DOI: https://doi.org/10.1007/978-1-4615-3030-5_20
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