Molecular Biology of the Prototype Arenavirus, Lymphocytic Choriomeningitis Virus
Structural analysis of a well-characterized virus such as lymphocytic choriomeningitis virus (LCMV) is of particular importance in interpret-ing complex biological phenomena. Complete determination of the nu-cleotide sequence of LCMV establishes the structural features and cod-ing capacity of the virus genome. It enables further studies on the gene expression and replication mechanisms of arenaviruses, with potential significance for our understanding of viral persistence and pathogenesis.
KeywordsZinc Cysteine Lysine Arginine Glutamine
Unable to display preview. Download preview PDF.
- DePolo, N. J., Giachetti, C., and Holland, J. J., 1987, Continuing co-evolution of virus and defective interfering particles and of viral genome sequences during undiluted passages: virus mutants exhibiting nearly complete resistance to formerly dominant defective interfering particles, J. Virol. 61:454.Google Scholar
- Matloubian, M., Somasundaram, T., Kolhekar, S. R., Selvakumar, R., and Ahmed, R., 1990, Genetic basis of viral persistence: Single amino acid change in the viral glycoprotein affects ability of lymphocytic choriomeningitis virus to persist in adult mice, J. Exp. Med. 172:1043.PubMedCrossRefGoogle Scholar
- Mitsutani, S., and Colonno, R. J., 1985, In vitro synthesis of an infectious RNA from cDNA clones of human rhinovirus type 14, J. Virol. 56:628.Google Scholar
- Oldstone, M. B. A., and Dixon, F., 1970, Pathogenesis of chronic disease associated with persistent lymphocytic choriomeningitis virus. II. Relationship of anti-lymphocytic choriomeningitis immune response to tissue injury in chronic lymphocytic choriomeningitis disease, J. Exp. Med. 131:1.PubMedCrossRefGoogle Scholar
- Rice, C. M., Levis, R., Strauss, J. H., and Huang, H. V., 1987, Production of infectious RNA transcripts from Sindbis virus cDNA clones: Mapping of lethal mutations, rescue of a temperature-sensitive marker, and in vitro mutagenesis to generate defined mutants, J. Virol. 61:3809.PubMedGoogle Scholar
- Riviere, Y., Ahmed, R., Southern, P. J., Buchmeier, M. J., and Oldstone, M. B. A., 1985b, Genetic mapping of lymphocytic choriomeningitis virus pathogenicity: Virulence in guinea pigs is associated with the L RNA segment, J. Virol. 55:704.Google Scholar
- Salvato, M., 1989, Ambisense nature of the L genomic segment of LCMV, in: Genetics and Pathogenicity of Negative Strand Viruses (B. Mahy and D. Kolakofsky, eds.), pp. 168–174. Elsevier Press, New York, Amsterdam.Google Scholar
- Salvato, M. S., Shimomaye, E. M., Schweighofer, K. S., and Oldstone, M. B. A., 1989a, Mapping genes of lymphocytic choriomeningitis virus which determine the cytotoxic T-lymphocyte response, in: Cell biology of virus entry, replication, and pathogenesis, UCLA Symp. Mol. Cell. Biol. 90:329.Google Scholar
- Salvato, M. S., Borrow, P., Shimomaye, E. M., and Oldstone, M. B. A., 1991, Molecular basis of viral persistence: as single amino acid change in the glycoprotein of lymphocytic choriomeningitis virus is associated with suppression of the antiviral cytotoxic T-lymphocyte response and establishment of persistence, J. Virol. 65:1863.PubMedGoogle Scholar
- Vezza, A C, Clewley, J. P., Gard, G. P., Abraham, N Z, Compans, R. W., and Bishop, D. H. L., 1978a, Virion RNA species of the Arenaviruses Pichinde, Tacaribe, and Tamiami, J. Virol. 26:485.Google Scholar
- Vezza, A. C., Gard, G. P., Compans, R. W., and Bishop, D. H. L., 1978b, Genetic and molecular studies of arenaviruses, in: Negative Strand Viruses and the Host Cell (B. W. J. Mahy and R. D. Barry, eds.), pp. 73. Academic Press. New York.Google Scholar
- Whitton, J. L., Tishon, A., Lewicki, H., Gebhard, J., Cook, T., Salvato, M. S., Joly, E., and Oldstone, M. B. A., 1989, Molecular analyses of a five-amino-acid cytotoxic T lymphocyte (CTL) epitope: An immunodominant region which induces nonreciprocal CTL cross-reactivity, J. Virol. 63:4303.PubMedGoogle Scholar