Polysialic Acid as a Regulator of Cell-Cell Interactions During Muscle Innervation
The study of cell-cell interactions in tissue formation has spanned several decades, with particularly rapid progress in recent years (for review see Rutishauser and Jessell, 1988). A fundamental hypothesis throughout has been that these interactions reflect specific molecular complementarity mediated by distinct components at the cell surface. In addition, it is generally assumed that the developmental control of interactions occurs through regulation of expression of the molecules directly involved. Thus many studies have interpreted the function of a particular cell interaction molecule on the basis of where and when it is detected in an embryo. That is, the burden of regulating cell-cell interactions is largely given to the control of genes that encode the relevant receptors.
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