Advertisement

Coronaviruses pp 471-472 | Cite as

Establishment of MHV-A59 S Protein Specific Cytotoxic T Lymphocyte Clones

  • Shigeru Kyuwa
  • Stephen A. Stohlman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 342)

Abstract

MHC class I-restricted cytotoxic T lymphocytes (CTL) are suggested to play an important role in protection, virus elimination and establishment of demyelinating disease in mouse hepatitis virus (MHV) infections 1–3. Recent studies suggest that CTL with appropriate T cell receptor recognizes a complex between a peptide derived from viral gene (CTL epitope) and a class I molecule and then destroys viral infected cell 4. In this paper, we attempted to analyze CTL epitope of MHV-A59 in BALB/c mice (H-2d).

Keywords

Demyelinating Disease Viral Infected Cell Recombinant Vaccinia Virus Mouse Hepatitis Virus Virus Elimination 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    M.A. Sussman, R.A. Shubin, S. Kyuwa and S.A. Stohlman, J. Virol. 63: 3051 (1989).PubMedGoogle Scholar
  2. 2.
    J.O. Fleming, F.I. Wang, M.D. Trousdale, D.R. Hinton and S.A. Stohlman, Adv. Exp. Med. Biol. 276: 565 (1990).PubMedCrossRefGoogle Scholar
  3. 3.
    K. Yamaguchi, N. Goto, S. Kyuwa, M. Hayami, Y. Toyoda, J.Neuroimmunol. 32: 1 (1991).PubMedCrossRefGoogle Scholar
  4. 4.
    O. Rotzschke and K. Falk, Immunol. Today 12: 447 (1991).PubMedCrossRefGoogle Scholar
  5. 5.
    K. Yamaguchi, S. Kyuwa, K. Nakanaga and M. Hayami, J. Virol. 62: 2505 (1988).PubMedGoogle Scholar
  6. 6.
    J.G. Keck, L.H. Soe, S. Makino, S.A. Stohlman and M.M.C. Lai, J. Virol. 62: 1989 (1988).PubMedGoogle Scholar
  7. 7.
    S. Makino, J.O. Fleming, J.G. Keck, S.A. Stohlman and M.M.C. Lai, Proc. Natl. Acad. Sci. USA 84: 6567 (1987).PubMedCrossRefGoogle Scholar
  8. 8.
    W. Luytjes, L.S. Sturman, P.J. Charite, B.A. van der Zeijst, M.C. Horzinek, W.J. Spaan, Virology 164: 479 (1987).CrossRefGoogle Scholar
  9. 9.
    J. Armstrong, S. Smeekens and P. Rottier, Nuc. Acid. Res. 11: 883 (1983)CrossRefGoogle Scholar
  10. 10.
    J. Armstrong, H. Niemann, S. Smeekens, P. Rottierand, G. Warren, Nature 308: 751 (1984).PubMedCrossRefGoogle Scholar
  11. 11.
    S.A. Stohlman, S. Kyuwa, M. Cohen, C. Bergmann, J.M. Polo, J. Yeh, R. Anthony and J.G. Keck, Virology 189: 217 (1992)PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Shigeru Kyuwa
    • 1
  • Stephen A. Stohlman
    • 1
    • 2
  1. 1.Department of NeurologyUniversity of Southern California School of MedicineLos AngelesUSA
  2. 2.Department of MicrobiologyUniversity of Southern California School of MedicineLos AngelesUSA

Personalised recommendations