Coronaviruses pp 471-472 | Cite as

Establishment of MHV-A59 S Protein Specific Cytotoxic T Lymphocyte Clones

  • Shigeru Kyuwa
  • Stephen A. Stohlman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 342)


MHC class I-restricted cytotoxic T lymphocytes (CTL) are suggested to play an important role in protection, virus elimination and establishment of demyelinating disease in mouse hepatitis virus (MHV) infections 1–3. Recent studies suggest that CTL with appropriate T cell receptor recognizes a complex between a peptide derived from viral gene (CTL epitope) and a class I molecule and then destroys viral infected cell 4. In this paper, we attempted to analyze CTL epitope of MHV-A59 in BALB/c mice (H-2d).


Demyelinating Disease Viral Infected Cell Recombinant Vaccinia Virus Mouse Hepatitis Virus Virus Elimination 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Shigeru Kyuwa
    • 1
  • Stephen A. Stohlman
    • 1
    • 2
  1. 1.Department of NeurologyUniversity of Southern California School of MedicineLos AngelesUSA
  2. 2.Department of MicrobiologyUniversity of Southern California School of MedicineLos AngelesUSA

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