Establishment of MHV-A59 S Protein Specific Cytotoxic T Lymphocyte Clones
MHC class I-restricted cytotoxic T lymphocytes (CTL) are suggested to play an important role in protection, virus elimination and establishment of demyelinating disease in mouse hepatitis virus (MHV) infections 1–3. Recent studies suggest that CTL with appropriate T cell receptor recognizes a complex between a peptide derived from viral gene (CTL epitope) and a class I molecule and then destroys viral infected cell 4. In this paper, we attempted to analyze CTL epitope of MHV-A59 in BALB/c mice (H-2d).
KeywordsDemyelinating Disease Viral Infected Cell Recombinant Vaccinia Virus Mouse Hepatitis Virus Virus Elimination