Seizure Frequency as Treatment Effect Parameter in Epileptic Patients: A Critical Appraisal of the Clinimetric Approach

  • A. Keyser
Part of the NATO ASI Series book series (NSSA, volume 255)


In the proposed “Guidelines for clinical evaluation of antiepileptic drugs” from the Commission on Antiepileptic Drugs of the International League Against Epilepsy (1987) “Seizure frequency” is one of the evaluation parameters from late phase I studies onwards. In phase II studies other seizure related parameters are added such as length of seizure-free intervals, seizure duration and seizure pattern.


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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • A. Keyser
    • 1
  1. 1.Institute of Neurology University Hospital StRadboud Catholic University, NijmegenNijmegenThe Netherlands

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