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Current Directions in Insulin-Like Growth Factor Research pp 79–89Cite as

Transcriptional Regulation of the Insulin Receptor Gene Promoter

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 343))

Abstract

The human insulin receptor is a membrane bound glycoprotein which is found on the surface of most cells. Like many growth factor receptors, the insulin receptor is a tyrosine kinase. The receptor is a heterotetramer composed of 2 alpha-and 2 beta-subunits. The alpha-subunit is located extracellularly where it binds insulin while the beta-subunit spans the membrane and contains the tyrosine kinase domain. The presence of this receptor is probably necessary for normal cell growth. Specialized cells such as myocytes and adipocytes have evolved mechanisms to elevate levels of this protein on their surface which allows these cells to be especially sensitive to the effects of insulin. In addition, the number of insulin receptor has been shown to be regulated by systemic factors such as hormones1 and nutrients such as glucose.2 Many investigators have cloned and analyzed the human insulin receptor promoter in an attempt to identify individual elements which are responsible for these effects. In this review, I will summarize the progress in this field and will discuss some of the conflicting data which has resulted.

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Author information

Authors and Affiliations

  1. Metabolic Diseases and Gene Therapy Research Program, National Institute of Diabetes and Kidney and Digestive Diseases, National Institutes of Health, Bethesda, MD, 20892, USA

    Catherine McKeon (Director)

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  1. Catherine McKeon
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Editors and Affiliations

  1. National Institutes of Health, Bethesda, Maryland, USA

    Derek Le Roith M.D., Ph.D.

  2. University of Florida, Gainesville, Florida, USA

    Mohan K. Raizada Ph.D.

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© 1994 Springer Science+Business Media New York

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McKeon, C. (1994). Transcriptional Regulation of the Insulin Receptor Gene Promoter. In: Le Roith, D., Raizada, M.K. (eds) Current Directions in Insulin-Like Growth Factor Research. Advances in Experimental Medicine and Biology, vol 343. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2988-0_9

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  • DOI: https://doi.org/10.1007/978-1-4615-2988-0_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6301-9

  • Online ISBN: 978-1-4615-2988-0

  • eBook Packages: Springer Book Archive

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