The Physiology and Pathophysiology of IGF-I In the Kidney

  • Raimund Hirschberg
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 343)

Abstract

Insulin-like growth factor I (IGF-I) is synthesized and released in the nephron1–10 and released into the systemic circulation by the kidneys11,12. Under normal conditions the glomerulus expresses IGF-I mRNA and releases IGF-I peptide1,2. Cell culture studies have shown that glomerular mesangial cells, which are mainly smooth muscle-like cells, express IGF-I13,14. Furthermore, cultured glomerular epithelial cells also release IGF-I (own unpublished observation). Within the nephron IGF-I is expressed in distal tubules and cortical collecting ducts but not in proximal tubules1–5. Scattered proximal tubule cells are positive for IGF-I mRNA by in-situ hybridization, suggesting that very small amounts of IGF-I may be synthesized under normal conditions1. In many tissues, growth hormone is the strongest secretagogue for IGF-I. In distal and collecting tubules the synthesis of IGF-I is growth hormone dependent15,16.

Keywords

Adenoma Angiotensin Histamine Prostaglandin Luminal 

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Raimund Hirschberg
    • 1
  1. 1.Division of Nephrology and HypertensionHarbor-UCLA Medical Center and UCLA School of MedicineTorranceUSA

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