Inhibition of Malignant Tumor Cell Invasion: An Approach to Anti-Progression

  • Adriana Albini
  • Annamaria Colacci
Part of the Basic Life Sciences book series (BLSC, volume 61)


Considerable attention should be given to primary prevention of neoplastic transformation. The best approaches to anticarcinogenesis are preventative measures to reduce exposure to environmental pollutants and improving life styles that may be responsible for genetic and epigenetic cell damage. Once neoplastic transformation has occurred, however, the major target of the oncologist becomes hindering tumor progression. It is difficult to define the onset of tumor progression and whether it involves a continous evolution or a step-like process. It is easier to define the consequence of tumor progression: malignant lesions with the ability to invade and to metastasize to distant organs. While benign tumors can often be cured simply by surgical removal, metastases remain the most frequent cause of cancer mortality.


Basement Membrane Melanoma Cell Metastatic Tumor Cell Experimental Metastasis Laminin Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Adriana Albini
    • 1
    • 2
  • Annamaria Colacci
    • 1
    • 2
  1. 1.Istituto Nazionale per la Ricerca sul CancroGenovaItaly
  2. 2.Biotechnology Satellite UnitIstituto Nazionale per la Ricerca sul CancroBolognaItaly

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