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Formation, Inhibition of Formation, and Repair of Oxidative 8-Hydroxyguanine DNA Damage

  • H. Kasai
  • M.-H. Chung
  • F. Yamamoto
  • E. Ohtsuka
  • J. Laval
  • A. P. Grollman
  • S. Nishimura
Part of the Basic Life Sciences book series (BLSC, volume 61)

Abstract

Oxygen radicals are produced by many carcinogenic agents and by ionizing radiation, and cause DNA damage in vitro and in vivo. Oxygen radicals are also produced in vivo during cellular metabolism of oxygen. Therefore, studies on DNA damage induced by oxygen radicals should be helpful in elucidating the mechanisms of induction of cancer by ionizing radiation and environmental chemicals as well as spontaneous carcinogenesis during aging.

Keywords

High Performance Liquid Chromatography Oxygen Radical Nickel Compound Cigarette Smoke Condensate Potassium Bromate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • H. Kasai
    • 1
  • M.-H. Chung
    • 2
  • F. Yamamoto
    • 1
  • E. Ohtsuka
    • 3
  • J. Laval
    • 4
  • A. P. Grollman
    • 5
  • S. Nishimura
    • 1
  1. 1.Biology DivisionNational Cancer Center Research InstituteTokyoJapan
  2. 2.Department of Pharmacy, College of MedicineSeoul National UniversitySeoulKorea
  3. 3.Department of Bioorganic Chemistry, Faculty of Pharmaceutical SciencesHokkaido UniversitySapporoJapan
  4. 4.Institut Gustave-RoussyVillejuifFrance
  5. 5.Department of Pharmaceutical SciencesState University of New YorkStony BrookUSA

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