Formation, Inhibition of Formation, and Repair of Oxidative 8-Hydroxyguanine DNA Damage
Oxygen radicals are produced by many carcinogenic agents and by ionizing radiation, and cause DNA damage in vitro and in vivo. Oxygen radicals are also produced in vivo during cellular metabolism of oxygen. Therefore, studies on DNA damage induced by oxygen radicals should be helpful in elucidating the mechanisms of induction of cancer by ionizing radiation and environmental chemicals as well as spontaneous carcinogenesis during aging.
KeywordsHigh Performance Liquid Chromatography Adduct Smoke Choline Quercetin
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- 1.Cheng, K.C., D.S. Cahill, H. Kasai, S. Nishimura, and L.A. Loeb (1991) The oxygen free radical associated DNA adduct 8-oxoguanine causes G•C to T•A transversions during in vivo DNA replication. Proceedings, Am. Assoc. Cancer Res. 32:149.Google Scholar
- 3.Djuric, Z., and D.W. Potter (1990) Oxidative DNA damage by 1,6 dinitropyrene in vivo. Proceedings, Am. Assoc. Cancer Res. 31:146.Google Scholar
- 4.Fiala, E.S., C.C. Conaway, and J.E. Mathis (1989) Oxidative DNA and RNA damage in the liver of Sprague-Dawley rats treated with the hepatocarcinogen 2-nitropropane. Cancer Res. 49:5518–5522.Google Scholar
- 7.Kasai, H., S. Nishimura (1983) Hydroxylation of the C-8 position of deoxyguanosine by reducing agents in the presence of oxygen. Nucl. Acids Res. Symp. Ser. 12:165–167.Google Scholar
- 9.Kasai, H., and S. Nishimura (1988) Formation of 8-hydroxdeooxyguanosine in DNA by auto-oxidized unsaturated fatty acids. In Medical, Biochemical and Chemical Aspects of Free Radicals ,O. Hayaishi, E. Niki, M. Kondo, and T. Yoshikawa, eds. Elsevier Science Publishers, pp. 1021–1023.Google Scholar
- 10.Kasai, H., and S. Nishimura (1991) Formation of 8-hydroxydeoxyguanosine in DNA by oxygen radicals and its biological significance. In Oxidative Stress, Oxidants and Antioxidants ,H. Sies, ed. Academic Press Ltd., pp. 99–116.Google Scholar
- 13.Kasai, H., Y. Okada, S. Nishimura, M.S. Rao, and J.K. Reddy (1989) Formation of 8-hydrooxydeoxyguanosine in liver DNA of rats following longterm exposure to a peroxisome proliferator. Cancer Res. 49:2603–2605.Google Scholar
- 14.Kasprzak, K.S., and L. Hernandez (1989) Enhancement of hydroxylation and deglycosylation of 2’-deoxyguanosine by carcinogenic nickel compounds. Cancer Res. 49:5964–5968.Google Scholar
- 15.Kasprzak, K.S., K. Higinbotham, B.A. Diwan, A.O. Perantoni, and J.M. Rice (1990) Correlation of DNA base oxidation with the activation of K~ras oncogene in nickel-induced renal tumors. Free Rad. Res. Comm. 9(Suppl. 1):l72.Google Scholar
- 19.Nakae, D., H. Yoshiji, H. Maruyama, T. Kinugasa, A. Denda, and Y. Knoishi (1990) Production of both 8-hydroxydeoyguanosine in liver DAN and g glutamyltransferase-positive hepatocellular lesion in rats given a cholinedeficient, L-amino acid-defined diet. Japan. J. Cancer Res. 81:1081–1084.CrossRefGoogle Scholar
- 21.Tchou, J., H. Kasai, S. Shibutani, M.H. Chung, J. Laval, A.P. Grollman, and S. Nishimura (1991) 8-Oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity. 88:4690–4694.Google Scholar
- 23.Wood, M.L., M. Dizdaroglu, E. Gajewski, and J.M. Essigmann (1990) Mechanistic studies of ionizing radiation and oxidative mutagenesis: Genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome. Biochemistry 29:7024–7032.PubMedCrossRefGoogle Scholar