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Consequences of Opiate-Dependency in a Monkey Model of AIDS

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Drugs of Abuse, Immunity, and AIDS

Abstract

In 1898, Cantacuzene (1) reported that rodent phagocytes exposed to morphine had reduced phagocytic and chemotactic activity in both in vitro and in vivo experimental systems. This work was carried out in the laboratory of the father of cell-mediated immunology, Elie Metchnikoff, and represents the first rigorous scientific study aimed at characterizing the immunological effects of opiates. About 10 years later, Archard et al., (2) corroborated the findings of Cantacuzene (1). By 1928, evidence indicating the immunomodulatory potential of opiates was reviewed by Terry and Pellens (3).

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Donahoe, R.M. et al. (1993). Consequences of Opiate-Dependency in a Monkey Model of AIDS. In: Friedman, H., Klein, T.W., Specter, S. (eds) Drugs of Abuse, Immunity, and AIDS. Advances in Experimental Medicine and Biology, vol 335. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2980-4_4

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  • DOI: https://doi.org/10.1007/978-1-4615-2980-4_4

  • Publisher Name: Springer, Boston, MA

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