Skip to main content

Natural Killer Cells and Cryptococcus Neoformans

  • Chapter
Drugs of Abuse, Immunity, and AIDS

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 335))

Abstract

Drugs of abuse that affect natural and acquired immune defenses could definitely alter an individuals susceptibility to life-threatening fungal infections. Although specific studies in which drugs of abuse have been used will not be reported here, it is anticipated that the ensuing discussion of the natural effector cells and their potential for limiting fungal infections may suggest how such drugs, especially those that alter natural killer (NK) cell and T cell functions, predispose an individual to infections with the yeast-like organism, Cryptococcus neoformans.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. J . Vandepitte, Clinical aspects of cryptococcosis in patients with AIDS, in: “Mycoses in AIDS Patients,” H. V. Bossche, D. W. R. Mackenzie, G. Cauwenbergh, J. V. Cutsem, E. Drouhet, and B. Dupont, eds., pp. 115, Plenum Press, New York (1990).

    Chapter  Google Scholar 

  2. S. L. Chuck, and M. A. Sande, Infections with Cryptococcus neoformans in the acquired immunodeficiency syndrome, N. Engl. J. Med. 321:794 (1989).

    Article  PubMed  CAS  Google Scholar 

  3. J. A. Kovacs, A. A. Kovacs, M. Polis, W. C. Wright, V. J. Gill, C. U. Tuazon, E. P. Gelmann, H. C. Lane, R. Longfield, G. Overturf, A. M. Macher, A. S. Fauci, J. E. Parrillo, J. E. Bennett and H. Masur, Cryptococcosis in the acquired immunodeficiency syndrome, Ann. Intern. Med. 103:533 (1985).

    PubMed  CAS  Google Scholar 

  4. J. O. Hill, CD4+ T cells cause multinucleated giant cells to form around Cryptococcus neoformans and confine the yeast within the primary site of infection in the respiratory tract, J. Exp. Med. 175:1685 (1992).

    Article  PubMed  CAS  Google Scholar 

  5. J. O. Hill, and A. G. Harmsen, Intrapulmonary growth and dissemination of an avirulent strain of Cryptococcus neoformans in mice depleted of CD4+ or CD8+ T-cells, J. Exp. Med. 173:755 (1991).

    Article  PubMed  CAS  Google Scholar 

  6. G. B. Huffnagle, J. L. Yates and M. F. Lipscomb, Immunity to a pulmonary Cryptococcus neoformans infection requires both CD4+ and CD8+ T cells, J. Exp. Med. 173:793 (1991).

    Article  PubMed  CAS  Google Scholar 

  7. C. H. Mody, M. F. Lipscomb, N. E. Street and G. B. Toews, Depletion of CD4+ (L3T4+) lymphocytes in vivo impairs murine host defense to Cryptococcus neoformans, J. Immunol. 144:1472 (1990).

    PubMed  CAS  Google Scholar 

  8. T. S. Lim, J. W. Murphy and L. K. Cauley, Host-etiological agent interactions in intranasally and intraperitoneally induced cryptococcosis in mice, Infect. Immun. 29:633 (1980).

    PubMed  CAS  Google Scholar 

  9. J . W. Murphy, Natural host resistance mechanisms against systemic mycotic agents, in: “Functions of the natural immune system,” C. W. Reynolds and R. H. Wiltrout, eds., pp. 149, Plenum Publishing Corp., New York. (1989).

    Chapter  Google Scholar 

  10. J . W. Murphy, Mechanisms of natural resistance to human pathogenic fungi, Ann. Rev. Microbiol. 45:509 (1991).

    Article  CAS  Google Scholar 

  11. M. F. Lipscomb, T. Alvarellos, G. B. Toews, R. Tompkins, Z. Evans, G. Koo and V. Kumar, Role of natural killer cells in resistance to Cryptococcus neoformans infections in mice, Am. J. Path. 128:354 (1987).

    PubMed  CAS  Google Scholar 

  12. M. R. Hidore, and J. W. Murphy, Correlation of natural killer cell activity and clearance of Cryptococcus neoformans from mice after adoptive transfer of splenic nylon wool-nonadherent cells, Infect. Immun. 51:547 (1986).

    PubMed  CAS  Google Scholar 

  13. M. R. Hidore, and J. W. Murphy, Natural cellular resistance of beige mice against Cryptococcus neoformans, J. Immunol. 137:3624 (1986).

    PubMed  CAS  Google Scholar 

  14. M. R. Hidore, and J. W. Murphy, Murine natural killer cell interactions with a fungal target, Cryptococcus neoformans, Infect. Immun. 57:1990 (1989).

    PubMed  CAS  Google Scholar 

  15. M. R. Hidore, N. Nabavi, C. W. Reynolds, P. A. Henkart and J. W. Murphy, Cytoplasmic components of natural killer cells limit the growth of Cryptococcus neoformans, J. Leuk. Biol. 48:15 1990).

    CAS  Google Scholar 

  16. M. R.Hidore, T. W. Mislan and J. W. Murphy, Responses of murine natural killer cells to binding of the fungal target Cryptococcus neoformans, Infect. Immun. 59:1489 (1991).

    PubMed  CAS  Google Scholar 

  17. M. R. Hidore, N. Nabavi, F. Sonleitner and J. W. Murphy, Murine natural killer cells are fungicidal to Cryptococcus neoformans, Infect. Immun. 5:1747 (1991).

    Google Scholar 

  18. J . W. Murphy, M. R. Hidore and N. Nabavi, Binding interactions of murine natural killer cells with the fungal target Cryptococcus neoformans, Infect. Immun. 59:1476 (1991).

    PubMed  CAS  Google Scholar 

  19. N. Nabavi, and J. W. Murphy, In vitro binding of natural killer cells to Cryptococcus neoformans targets, Infect. Immun. 50:50 (1985).

    PubMed  CAS  Google Scholar 

  20. S. R. Targen, and R. L. Deem, NK-target cell interactions in binding, triggering, programming, and lethal hit of NK cytotoxicity, in: “Mechanisms of Cytotoxicity by NK Cells,” R. B. Herberman and D. M. Callewaert, eds., pp. 155–172, Academic Press, Orlando, Fla. (1985).

    Google Scholar 

  21. J . C. Roder, R. Kiessling, P. Biberfeld and B. Andersson, Target-effector interaction in the natural killer (NK) cell system, II. The isolation of NK cells and studies on the mechanism of killing, J. Immunol. 121:2509 (1978).

    PubMed  CAS  Google Scholar 

  22. M. F. Miller, T. G. Mitchell, W. J. Storkus and J. R. Dawson, Human natural killer cells do not inhibit growth of Cryptococcus neoformans in the absence of antibody, Infect. Immun. 58:639 (1990).

    PubMed  CAS  Google Scholar 

  23. J . W. Murphy, M. R. Hidore, and C. S. Wong, Direct interactions of human lymphocytes with the yeast-like organism, Cryptococcus neoformans, J. Clin. Invest ,(in press) (1993).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer Science+Business Media New York

About this chapter

Cite this chapter

Murphy, J.W. (1993). Natural Killer Cells and Cryptococcus Neoformans . In: Friedman, H., Klein, T.W., Specter, S. (eds) Drugs of Abuse, Immunity, and AIDS. Advances in Experimental Medicine and Biology, vol 335. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2980-4_37

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-2980-4_37

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6297-5

  • Online ISBN: 978-1-4615-2980-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics