Abstract
Drugs of abuse that affect natural and acquired immune defenses could definitely alter an individuals susceptibility to life-threatening fungal infections. Although specific studies in which drugs of abuse have been used will not be reported here, it is anticipated that the ensuing discussion of the natural effector cells and their potential for limiting fungal infections may suggest how such drugs, especially those that alter natural killer (NK) cell and T cell functions, predispose an individual to infections with the yeast-like organism, Cryptococcus neoformans.
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References
J . Vandepitte, Clinical aspects of cryptococcosis in patients with AIDS, in: “Mycoses in AIDS Patients,” H. V. Bossche, D. W. R. Mackenzie, G. Cauwenbergh, J. V. Cutsem, E. Drouhet, and B. Dupont, eds., pp. 115, Plenum Press, New York (1990).
S. L. Chuck, and M. A. Sande, Infections with Cryptococcus neoformans in the acquired immunodeficiency syndrome, N. Engl. J. Med. 321:794 (1989).
J. A. Kovacs, A. A. Kovacs, M. Polis, W. C. Wright, V. J. Gill, C. U. Tuazon, E. P. Gelmann, H. C. Lane, R. Longfield, G. Overturf, A. M. Macher, A. S. Fauci, J. E. Parrillo, J. E. Bennett and H. Masur, Cryptococcosis in the acquired immunodeficiency syndrome, Ann. Intern. Med. 103:533 (1985).
J. O. Hill, CD4+ T cells cause multinucleated giant cells to form around Cryptococcus neoformans and confine the yeast within the primary site of infection in the respiratory tract, J. Exp. Med. 175:1685 (1992).
J. O. Hill, and A. G. Harmsen, Intrapulmonary growth and dissemination of an avirulent strain of Cryptococcus neoformans in mice depleted of CD4+ or CD8+ T-cells, J. Exp. Med. 173:755 (1991).
G. B. Huffnagle, J. L. Yates and M. F. Lipscomb, Immunity to a pulmonary Cryptococcus neoformans infection requires both CD4+ and CD8+ T cells, J. Exp. Med. 173:793 (1991).
C. H. Mody, M. F. Lipscomb, N. E. Street and G. B. Toews, Depletion of CD4+ (L3T4+) lymphocytes in vivo impairs murine host defense to Cryptococcus neoformans, J. Immunol. 144:1472 (1990).
T. S. Lim, J. W. Murphy and L. K. Cauley, Host-etiological agent interactions in intranasally and intraperitoneally induced cryptococcosis in mice, Infect. Immun. 29:633 (1980).
J . W. Murphy, Natural host resistance mechanisms against systemic mycotic agents, in: “Functions of the natural immune system,” C. W. Reynolds and R. H. Wiltrout, eds., pp. 149, Plenum Publishing Corp., New York. (1989).
J . W. Murphy, Mechanisms of natural resistance to human pathogenic fungi, Ann. Rev. Microbiol. 45:509 (1991).
M. F. Lipscomb, T. Alvarellos, G. B. Toews, R. Tompkins, Z. Evans, G. Koo and V. Kumar, Role of natural killer cells in resistance to Cryptococcus neoformans infections in mice, Am. J. Path. 128:354 (1987).
M. R. Hidore, and J. W. Murphy, Correlation of natural killer cell activity and clearance of Cryptococcus neoformans from mice after adoptive transfer of splenic nylon wool-nonadherent cells, Infect. Immun. 51:547 (1986).
M. R. Hidore, and J. W. Murphy, Natural cellular resistance of beige mice against Cryptococcus neoformans, J. Immunol. 137:3624 (1986).
M. R. Hidore, and J. W. Murphy, Murine natural killer cell interactions with a fungal target, Cryptococcus neoformans, Infect. Immun. 57:1990 (1989).
M. R. Hidore, N. Nabavi, C. W. Reynolds, P. A. Henkart and J. W. Murphy, Cytoplasmic components of natural killer cells limit the growth of Cryptococcus neoformans, J. Leuk. Biol. 48:15 1990).
M. R.Hidore, T. W. Mislan and J. W. Murphy, Responses of murine natural killer cells to binding of the fungal target Cryptococcus neoformans, Infect. Immun. 59:1489 (1991).
M. R. Hidore, N. Nabavi, F. Sonleitner and J. W. Murphy, Murine natural killer cells are fungicidal to Cryptococcus neoformans, Infect. Immun. 5:1747 (1991).
J . W. Murphy, M. R. Hidore and N. Nabavi, Binding interactions of murine natural killer cells with the fungal target Cryptococcus neoformans, Infect. Immun. 59:1476 (1991).
N. Nabavi, and J. W. Murphy, In vitro binding of natural killer cells to Cryptococcus neoformans targets, Infect. Immun. 50:50 (1985).
S. R. Targen, and R. L. Deem, NK-target cell interactions in binding, triggering, programming, and lethal hit of NK cytotoxicity, in: “Mechanisms of Cytotoxicity by NK Cells,” R. B. Herberman and D. M. Callewaert, eds., pp. 155–172, Academic Press, Orlando, Fla. (1985).
J . C. Roder, R. Kiessling, P. Biberfeld and B. Andersson, Target-effector interaction in the natural killer (NK) cell system, II. The isolation of NK cells and studies on the mechanism of killing, J. Immunol. 121:2509 (1978).
M. F. Miller, T. G. Mitchell, W. J. Storkus and J. R. Dawson, Human natural killer cells do not inhibit growth of Cryptococcus neoformans in the absence of antibody, Infect. Immun. 58:639 (1990).
J . W. Murphy, M. R. Hidore, and C. S. Wong, Direct interactions of human lymphocytes with the yeast-like organism, Cryptococcus neoformans, J. Clin. Invest ,(in press) (1993).
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Murphy, J.W. (1993). Natural Killer Cells and Cryptococcus Neoformans . In: Friedman, H., Klein, T.W., Specter, S. (eds) Drugs of Abuse, Immunity, and AIDS. Advances in Experimental Medicine and Biology, vol 335. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2980-4_37
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DOI: https://doi.org/10.1007/978-1-4615-2980-4_37
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