Molecular Mechanisms Associated with Cocaine-Induced Modulation of Human T Lymphocytes Proliferation
The increasing abuse of cocaine by young adults and the many deaths attributed to cocaine overdose have prompted questions concerning the public health risk of abusing the drug. These deaths result from a combination of drug effects on both the central and sympathetic nervous systems (1). In addition to the lethal toxic effects of cocaine, previous reports demonstrated that cocaine has various influences, both suppression and enhancement, on the immune function of humans and experimental animals (2, 3, 4, 5). However, the mechanisms of immunomodulation in vivo are unclear, because cocaine can act either as a local anesthetic or systemically through the central nervous system.
KeywordsMgCl Cocaine CaCl Cytosol EGTA
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