Abstract
The combination of boron-containing drugs and neutron irradiation to combat certain brain cancers has proven to be a viable method for cancer treatment. The effectiveness of this treatment depends on the selectivity of the carrier compound delivering boron to the tumor cells. To date, the most effective brain tumor treatment drug is borocaptate sodium(Na2B12H11SH or BSH). As new drugs are constantly being synthesized to improve selective delivery of boron to cancer cells any analytical technique capable of quantifying boron at the subcellular level will play an important role in determining the drug’s potency for boron neutron capture therapy (BNCT).
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© 1993 Springer Science+Business Media New York
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Chia, V.K.F. et al. (1993). Quantification of Boron in Biological Tissue by Secondary Ion Mass Spectrometry. In: Soloway, A.H., Barth, R.F., Carpenter, D.E. (eds) Advances in Neutron Capture Therapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2978-1_84
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DOI: https://doi.org/10.1007/978-1-4615-2978-1_84
Publisher Name: Springer, Boston, MA
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