Relation between Structures of p-Boronopiienylalanine Related Compounds and Their Usefulness for Boron Neutron Capture Therapy
10B-compounds are taken up by cancer cells by two different mechanisms: 1) Biophysical uptake, and 2) Biochemical uptake. The actual uptake is a combination of these two.
KeywordsChrome Saccharide Tyrosine Boron Fructose
Unable to display preview. Download preview PDF.
- 1.K. Yoshino, H. Kakihana, M. Okamoto, and Y. Mori, Chemical behavior of dopaborate and 10B-p-Boronophenylalanine, in: “ Neutron Capture Therapy” H. Hatanaka ed., Nishimura Co., Ltd., Niigata, Japan (1986).Google Scholar
- 2.K. Yoshino, A. Suzuki, Y. Mori, H. Kakihana, C. Honda, Y. Mishima, T. Kobayashi, and K. Kanda, Improvement of solubility of p-boronophenylalanine by complex formation with monosaccharides, Strahlenther. Onlcol. 165, 127–129 (1989).Google Scholar
- 5.K. Yoshino, T. Maruyama, Y. Mori, H. Kakihana, and Y. Mishima, Capture of p-Boronophenylalanine by melanin-related compounds: Complex formation of p-Boronophenylalanine with L-Dopa. in: “Advances in Neutron Capture Therapy”, A.H. Soloway, et al. ed., This symposium proceedings.Google Scholar
- 6.K. Yoshino, H. Kakihana, Y. Mori, N. Torii, H. Takahashi, and Y. Mishima, Proposed mechanism of capture and release of p-boronophenylalanine through melanom cells: Chemical behaviour of p-boronophenylalanine-fructose complex in L-Dopa solution. in:“Advances in Neutron Capture Therapy”, A.H. Soloway, et al. ed., This symposium proceedings.Google Scholar
© Springer Science+Business Media New York 1993