Abstract
A key to successful gadolinium neutron capture therapy (GNCT) is to sustain an appropriate concentration of 157Gd in the tumor during neutron irradiation. Currently, experimental GNCT studies are being carried out using meglumine gadopentetate (MG), a contrast medium for magnetic resonance imaging (Akine et al., 1990). MG visualizes tumors when given intravenously, but its rapid clearance makes it less suitable for GNCT. Recently, MG-containing microcapsules have become available with an improved retention time in vivo (Fukumori et al., 1993). In this communication we report our preliminary results using these two forms of gadolinium carriers in two different models: one study involving MG given subcutaneously with tumor cells; the other with MG-containing microcapsules given intraperitoneally along with tumor cells.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Akine, Y., Tokita, N., Matsumoto, H., Oyama, H., Egawa, S. and Aizawa, O., 1990, Radiation effect of gadolinium-neutron capture reactions on the survival of Chinese hamster cells. Strahlenther Onkol 166: 831.
Akine, Y., Tokita, N., Matsumoto, T., Oyama, H. and Aizawa, O., 1992a, Gadolinium-neutron capture reactions: a radiobiological assay, in: “Progress in Neutron Capture Therapy for Cancer”, B. J. Allen, D. E. Moore, B.V. Harrington, eds., Plenum Press, New York, p361.
Akine, Y., Tokita, N., Tokuuye, K., Satoh, M., Fukumori, Y., Tokumitsu, H., Kanamori, R., Kobayashi, T. and Kanda, K., 1992b, Neutron-capture therapy of murine ascites tumor with gadolinium-containing microcapsules, J Cancer Res Clin Oncol 119: 71.
Fukumori, Y., Ichikawa, H., Tokumitsu, H., Miyamoto, M., Jono, K., Kamamori, R., Akine, Y. and Tokita, N., 1993, Design and preparation of ethyl cellulose microcapsules of gadopentetate dimeglumine for neutron capture therapy by means of Wurster process, Chem Pharm Bull in press.
Tokuuye, K., Tokita, N., Akine, Y., Kobayashi, T. and Kanda, K., 1992, Biological dosimetry for gadolinium neutron capture reaction (abstract), In; The fifth International Symposium on Neutron Capture Therapy, Columbus, Ohio, USA.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer Science+Business Media New York
About this chapter
Cite this chapter
Akine, Y. et al. (1993). Gadolinium Neutron Capture Therapy: Growth Suppression of Ehrlich Ascites and Subcutaneously-Implanted Tumor Cells in Mice. In: Soloway, A.H., Barth, R.F., Carpenter, D.E. (eds) Advances in Neutron Capture Therapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2978-1_48
Download citation
DOI: https://doi.org/10.1007/978-1-4615-2978-1_48
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6296-8
Online ISBN: 978-1-4615-2978-1
eBook Packages: Springer Book Archive