Analytical Dose Calculation in Cell Nucleus from Spherical 10B Containing Region and a Concept of RBE for Neutron Capture Therapy
For ordinary radiation therapy, such as X rays, gamma rays, or electron beams, the average absorbed dose over the order of millimeters is sufficient to estimate a therapeutic effect. On the other hand, boron neutron capture therapy (BNCT) utilizes high-LET particles of short range such as α particles and 7Li nuclei produced by neutron reactions with 10B. The range of the local destruction covers cells containing 10B and their adjacent cells, since the ranges of α particles and 7Li nuclei are almost the same as a typical cell diameter of 10 μm. The advantage of this therapy is the selective destruction by neutron reactions of only the tumor into which 10B compound has been previously injected. The therapeutic result is sensitive to variations in the absorbed dose distribution in a cell. In the other word, BNCT has the possibility of selective treatment at the cell level.
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- 3.T. Kobayashi and K. Kanda, “Boron-10 Dosage in Cell Nucleus for Neutron Capture Therapy -- Boron Selective Dose Ratio”, Boron—Neutron Capture Therapy for Tumors, (Edit. H.Hatanaka) Nishimura Japan (1986) 293–300.Google Scholar