Analytical Dose Calculation in Cell Nucleus from Spherical 10B Containing Region and a Concept of RBE for Neutron Capture Therapy

  • Tooru Kobayashi
  • Keiji Kanda

Abstract

For ordinary radiation therapy, such as X rays, gamma rays, or electron beams, the average absorbed dose over the order of millimeters is sufficient to estimate a therapeutic effect. On the other hand, boron neutron capture therapy (BNCT) utilizes high-LET particles of short range such as α particles and 7Li nuclei produced by neutron reactions with 10B. The range of the local destruction covers cells containing 10B and their adjacent cells, since the ranges of α particles and 7Li nuclei are almost the same as a typical cell diameter of 10 μm. The advantage of this therapy is the selective destruction by neutron reactions of only the tumor into which 10B compound has been previously injected. The therapeutic result is sensitive to variations in the absorbed dose distribution in a cell. In the other word, BNCT has the possibility of selective treatment at the cell level.

Keywords

Boron 

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References

  1. 1.
    T. Kobayashi and K. Kanda, “Analytical Calculation of Boron-10 Dosage in Cell Nucleus for Neutron Capture Therapy”, Radiat. Res., 91 (1982) 77–94.PubMedCrossRefGoogle Scholar
  2. 2.
    A. Soloway, A. K. M. Anisuzzaman, L. Liu, R. F. Barth, F. Alam, W. Tjarks, “Carboranyl Precursors of Nucleic Acids -- Potential DNA Probes for BNCT”, Progress in Neutron Capture Therapy for Cancer (Ed. B.Allen et al.) Plenum NY (1992) 207–210.CrossRefGoogle Scholar
  3. 3.
    T. Kobayashi and K. Kanda, “Boron-10 Dosage in Cell Nucleus for Neutron Capture Therapy -- Boron Selective Dose Ratio”, Boron—Neutron Capture Therapy for Tumors, (Edit. H.Hatanaka) Nishimura Japan (1986) 293–300.Google Scholar
  4. 4.
    H. Fukuda, T. Kobayashi, T. Matsuzawa, K. Kanda, M. Ichihashi and Y. Mishima, “RBEs of a Thermal Neutron Beam and the 10B(n,α)7Li Reaction on Cultured B-16 Melanoma Cells”, Int. J. Radiat. Biol., 51 (1987) 167–175.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Tooru Kobayashi
    • 1
  • Keiji Kanda
    • 1
  1. 1.Research Reactor InstituteKyoto UniversityOsakaJapan

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