A Comparison of the Dose-Rbe and the Biological Dosimetry Approaches for Treatment Planning in Bnct
Treatment planning for clinical trials with boron neutron capture therapy (BNCT) is complicated substantially by the fact that the radiation field generated by the activating external neutron beam is composed of several different types of radiation, i.e., fast neutrons, recoil protons from elastic collisions with hydrogen, gamma rays from the reactor and from neutron capture by body hydrogen, protons from nitrogen capture, and the products of the NCT interaction. Furthermore, the relative contribution of each type of radiation varies with depth in tissue. Because each of these radiations has its own RBE, and the RBE of the fast neutron component will not be constant as the neutron spectrum changes with depth, the problem of predicting the severity of the biological effect, in depth, becomes complex indeed.
KeywordsToxicity Boron Hydride Porphyrin Bismuth
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- 3.H.B. Liu and R.M. Brugger, Dose calculation and treatment planning for the Brookhaven NCT facility, in: Proceedings of the Fifth International Symposium on Neutron Capture Therapy. Plenum Press (1993).Google Scholar
- 5.R.G. Fairchild, S.B. Kahl, B.H. Laster, J. Kalef-Ezra and E.A. Popenoe, In vitro determination of uptake, retention, distribution, biological efficacy, and toxicity of boronated compounds for neutron capture therapy:A comparison of porphyrins with sulfhydryl boron hydrides. Cancer Res. 50:4860–4865 (1990).PubMedGoogle Scholar