Dose Optimization for Boron Neutron Capture Therapy of Spontaneous Canine Brain Tumors
The ultimate success of Boron Neutron Capture Therapy (BNCT) will depend, among other things, upon the ability to calculate, a priori, accurate and optimal radiation dose distributions in the target volume. Twenty-one dogs with spontaneously-occurring brain tumors have been treated, at the Brookhaven Medical Research Reactor (BMRR) in a collaborative effort between the Idaho National Engineering Laboratory (INEL), Washington State University (WSU), and Brookhaven National Laboratory (BNL). Because these 21 treatments were designed to demonstrate safety rather than efficacy, the dogs involved did not necessarily receive irradiations corresponding to a treatment plan designed to maximize the estimated cell kill at the target location. Four of these dogs (with intra-axial tumors above the tentorium) were chosen as test cases to determine the effects of optimizing treatment. Although the tumors present in all four dogs were of the same type, they varied significantly in size and location. Optimum treatment was found by varying boron concentration and incident neutron beam position and size. The effect of using a beam having a “cleaner,” more forward-peaked angular distribution [Georgia Tech Research Reactor (GTRR)] was also examined.
KeywordsNeutron Source Tumor Cell Kill Boron Neutron Capture Therapy Relative Biological Effectiveness Brookhaven National Laboratory
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- 1.F.J. Wheeler and D.W. Nigg, “Three-Dimensional Radiation Dose Distribution Analysis for Boron Neutron Capture Therapy,” Nuclear Science and Engineering, 110, January, 1992, pp. 16–31.Google Scholar
- 2.F.J. Wheeler, D.K. Parsons, B.L. Rushton, and D.W. Nigg, “Epithermal Neutron Beam Design for Neutron Capture Therapy at the Power Burst Facility and the Brookhaven Medical Research Reactor,” Nuclear Technology, 92,October, 1990, pp. 106–117.Google Scholar
- 3.D.W. Nigg, G.J. Story, and F.J. Wheeler, “Physics Parameters for an Epithermal-Neutron Beam at the Georgia Institute of Technology”, Proceedings of the Fifth International Symposium on Neutron Capture Therapy, Columbus, Ohio,September 14–17, 1992,these proceedings.Google Scholar
- 4.D. Gabel, R.G. Fairchild, B. Larsson, K. Drescher, and W.R. Rowe, “The Biological Effect of the 10B(n,α)7Li Reaction and its Simulation by Monte Carlo Calculation,” Proceedings of the First International Symposium on Neutron Capture Therapy, Cambridge, Massachusetts,October 12–14, 1983, BNL 51730, Brookhaven National Laboratory, R.G. Fairchild and G.L. Brownell, editors, p.128.Google Scholar
- 6.P.R. Gavin, F.J. Wheeler, R. Huiskamp, A. Siefert, S.L. Kraft, and C.E. DeHaan, “Large Animal Model Studies of Normal Tissue Tolerance Using an Epithermal-Neutron Beam and Borocaptate Sodium,” Proceedings of the International Workshop on Macro and Microdosimetry and Treatment Planning for Neutron Capture Therapy, Massachusetts Institute of Technology,Cambridge, Massachusetts,October 31 - November 1, 1991,to be published.Google Scholar
- 7.K.F. Fu, Influence of dose rate on normal tissue tolerance, in: “Radiation Injury to the Nervous System,” P.H. Gutin, S.A. Leibel & G.E. Sheline, eds., Raven Press, New York, 1991, pp.69–87.Google Scholar