Dose Optimization for Boron Neutron Capture Therapy of Spontaneous Canine Brain Tumors
The ultimate success of Boron Neutron Capture Therapy (BNCT) will depend, among other things, upon the ability to calculate, a priori, accurate and optimal radiation dose distributions in the target volume. Twenty-one dogs with spontaneously-occurring brain tumors have been treated, at the Brookhaven Medical Research Reactor (BMRR) in a collaborative effort between the Idaho National Engineering Laboratory (INEL), Washington State University (WSU), and Brookhaven National Laboratory (BNL). Because these 21 treatments were designed to demonstrate safety rather than efficacy, the dogs involved did not necessarily receive irradiations corresponding to a treatment plan designed to maximize the estimated cell kill at the target location. Four of these dogs (with intra-axial tumors above the tentorium) were chosen as test cases to determine the effects of optimizing treatment. Although the tumors present in all four dogs were of the same type, they varied significantly in size and location. Optimum treatment was found by varying boron concentration and incident neutron beam position and size. The effect of using a beam having a “cleaner,” more forward-peaked angular distribution [Georgia Tech Research Reactor (GTRR)] was also examined.
KeywordsBoron Oligodendroglioma Carol
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