Retinal Degenerations in the Briard Dog

  • P. Watson
  • A. Wrigstad
  • R. C. Riis
  • K. Narfstrom
  • P. G. C. Bedford
  • S. E. G. Nilsson


Retinal degeneration in the Briard dog has been described by a number of authors in different countries. Congenital night blindness has been reported in the USA1 and in France2. In Sweden, the first Briards studied were congenitally night blind3, but in successive generations of dogs day vision also became affected4,5. In contrast, a slowly progressive central retinal degeneration has been reported in the United Kingdom6. These dogs had apparently normal vision initially with no evidence of night blindness, but severe visual impairment developed with time. The problem in the USA has been referred to as the Briard lipid retinopathy, the problem in France simply as congenital night blindness and the problem in Sweden as congenital night blindness with severely reduced day vision. The condition reported in the UK has been referred to as central progressive retinal atrophy (cPRA) or retinal pigment epithelial dystrophy (RPED).


Retinal Pigment Epithelium Retinal Pigment Epithelium Cell Retinitis Pigmentosa Outer Segment Retinal Degeneration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    R.C. Riffs and G.D. Aguirre, The Briard problem, Procedings of the American College of Veterinary Ophthalmology. Chicago (1983).Google Scholar
  2. 2.
    M. Roze, A. Lucciana, J. Capodano, S. Gambarelli, and M. Auphan, The Briard problem in France, the retina, light microscopy, electron microscopy, retinal antigen, Procedings of the International Society for Veterinary Ophthalmology. Vienna (1991).Google Scholar
  3. 3.
    K. Narfstrom, A. Wrigstad, and S.E.G. Nilsson, The Briard dog: A new animal model of congenital stationary night blindness, Br. J. Ophthalmol. 73:750–756 (1989).PubMedCrossRefGoogle Scholar
  4. 4.
    S.E.G. Nilsson, A. Wrigstad, and K. Narfstrom, Congenital night blindness and partial day blindness in the Briard dog. In.. “Retinal Degenerations”, R.E. Anderson, J.G. Hollyfield, M.M. LaVail, Eds. CRC Press, Inc. Boca Raton, Ann Arbor, Boston, London (1991).Google Scholar
  5. 5.
    A. Wrigstad, S.E.G. Nilsson and K. Narfstrom, Ultrastructural changes of the retina and the retinal pigment epithelium in Briard dogs with hereditary congenital night blindness and partial day blindness, Exp. Eye Res. (In Press).Google Scholar
  6. 6.
    P.G.C. Bedford, Retinal pigment epithelial dystrophy (cPRA): a study of the disease in the Briard. J. Small Anim. Pract. 25:129–138 (1984).CrossRefGoogle Scholar
  7. 7.
    M. Roze, The Briard problem in France, clinical and breed study. Procedings of the International Society for Veterinary Ophthalmology. Vienna (1991).Google Scholar
  8. 8.
    K. Narfstrom, A. Wrigstad and S.E.G. Nilsson, Congenital night blindness and partially reduced day vision in the Briard dog: Clinical and laboratory findings. Procedings of the International Society for Veterinary Ophthalmology. Vienna (1991).Google Scholar
  9. 9.
    A. Wrigstad, K. Narfstrom and S.E.G. Nilsson, Morphological changes in the retina and RPE in Briard dogs with congenital night blindness and partial day blindness are slowly progressive. Invest. Ophthalmol. Vis. Sci. 33: 1065 (1992).Google Scholar
  10. 10.
    S.E.G. Nilsson, A. Wrigstad and K. Narfstrom, Changes in the DC electroretinogram in Briard dogs with hereditary congenital night blindness and partial day blindness. Exp. Eye Res. 54: 291–296 (1992).PubMedCrossRefGoogle Scholar
  11. 11.
    R. Lightfoot, Retinal pigment epithelial dystrophy in the Briard. Thesis. University of London (1988).Google Scholar
  12. 12.
    R.C. Ibis and A.B. Siakotos, Inherited lipid retinopathy in a dog breed. Procedings of the American College of Veterinary Ophthalmology. (1989).Google Scholar
  13. 13.
    P. Watson, K.W. Simpson and P.G.C. Bedford, Hypercholesterolaemia in Briards in the United Kingdom. Res. Vet. Sci. In Press.Google Scholar
  14. 14.
    P. Watson, G. Anantharaman, J. Vichoud and P.G.C. Bedford, Antioxidant status of Briards with retinal pigment epithelial dystrophy. Procedings of the World Small Animal Veterinary Association.. Rome (1992).Google Scholar
  15. 15.
    H.B. Parry, Degenerations of the dog retina. VI. Central progressive atrophy with pigment epithelial dystrophy. Brit. J. Ophthalmol. 38: 653–668 (1954).CrossRefGoogle Scholar
  16. 16.
    D.A. Witzel, E.L. Smith, R.D. Wilson and G.D. Aguirre, Congenital stationary night blindness: an animal model. Invest. Ophthalmol. Vis. Sci. 17: 788–795.1978.PubMedGoogle Scholar
  17. 17.
    R.E. Carr, H. Ripps, I.M. Siegel, and R.A. Weale, Rhodopsin and the electrical activity of the retina in congenital night blindness. Invest. Ophthalmol. 5: 497–507 (1966).PubMedGoogle Scholar
  18. 18.
    A.E. Leure-duPree, Electron-opaque inclusions in the rat retinal pigment epithelium after treatment with chelators of zinc. Invest. Ophthalmol. Vis. Sci. 21:1–9 (1981).PubMedGoogle Scholar
  19. 19.
    G.D. Aguirre and A. Laties, Pigment epithelial dystrophy in the dog. Exp. Eye Res. 23:247–256. (1976).PubMedCrossRefGoogle Scholar
  20. 20.
    R.W. Young, A theory of central retinal disease. In: “New directions in ophthalmic research”. M.L. Sears, Ed., Yale University Press. New Haven (1981).Google Scholar
  21. 21.
    R.D. Jolly and R.R. Dalefield, Lipopigments in veterinary pathology: Pathogenesis and terminology. Adv. Exp. Med. Biol. 266: 157–167 (1989).PubMedGoogle Scholar
  22. 22.
    L. Feeney-Burns and G.E. Eldred, The fate of the phagosome: Conversion to “age pigment” and impact in human retinal pigment epithelium. Trans. Ophthalmol. Soc. UK. 103: 416–421 (1984).Google Scholar
  23. 23.
    M.L. Katz, and W.G. Robison, Age-related changes in the retinal pigment epithelium of pigmented rats. Exp. Eye Res. 38: 137–151 (1984).PubMedCrossRefGoogle Scholar
  24. 24.
    M. Boulton, Ageing of the retinal pigment epithelium. In: “Progress in Retinal Research, Vol. 11”. N.N. Osborne and G.J. Chader, Eds. Pergamon Press. Oxford (1991).Google Scholar
  25. 25.
    G.E. Eldred and M.L. Katz, The lipid peroxidation theory of lipofuscinogenesis cannot yet be confirmed. Free Rad. Biol. Med. 10: 445–447 (1991).PubMedCrossRefGoogle Scholar
  26. 26.
    M. Ostrovsky, N.L. Sakina and A.E. Dontsov, An antioxidative role for ocular screening pigments. Vision Res. 27: 893–899 (1987).PubMedCrossRefGoogle Scholar
  27. 27.
    R.C. Riffs, B.E. Sheffy, E. Loew, T.J. Kern and J.S. Smith, Vitamin E retinopathy in dogs. Am. J. Vet. Res. 42: 74–86 (1981).Google Scholar
  28. 28.
    M.L. Katz, W.L. Stone and E.A. Dratz, Fluorescent pigment accumulation in retinal pigment epithelium of antioxidant deficient rats. Invest. Ophthalmol.Vis. Sci. 17: 1049–1057 (1978).PubMedGoogle Scholar
  29. 29.
    N.G. Bazan, B.L. Scott, T.S. Reddy and M.Z. Pelias, Decreased content of docosahexaenoate and arachidonate in plasma phospholipids in Usher’s syndrome. Biochem. Biophys. Res. Comm. 141: 600–604 (1986).PubMedCrossRefGoogle Scholar
  30. 30.
    C.A. Converse, T. McLachlan, A.C. Bow, C.J. Packard and J. Shepherd, Lipid metabolism in retinitis pigmentosa. In: “Degenerative Retinal Disorders: Clinical and Laboratory Investigations.” J.G. Hollyfield, R.E. Anderson and M.M. LaVail, Eds. Alan R. Liss, Inc. New York. (1987).Google Scholar
  31. 31.
    R.E. Anderson, M.B. Maude, R.A. Alvarez, G.M. Acland and G.D. Aguirre, Plasma levels of docosahexaenoic acid in miniature poodles with an inherited retinal degeneration. Invest. Ophthalmol. Vis. Sci. 29 (Supplement): 169 (1988).Google Scholar
  32. 32.
    J. Gong, B. Rosner, D.G. Rees, E.L. Berson, C.A. Weigel-DiFranco and E.J. Schaefer, Plasma docosahexanoic acid levels in various genetic forms of retinitis pigmentosa. Invest. Ophthalmol. Vis. Sci. 33: 2596–2602 (1992).PubMedGoogle Scholar
  33. 33.
    M.G. Wetzel, C. Fahlman, M.B. Maude, R.A. Alvarez, P.J. O’Brien, G.M. Acland, G.D. Aguirre and R.E. Anderson, Fatty acid metabolism in normal miniature poodles and those affected with progressive rod cone degeneration (prcd). In: “Inherited and Environmentally Induced Retinal Degenerations”. M.M. LaVail, R.E. Anderson and J.G. Hollyfield, Eds. Alan R. Liss, Inc. New York (1989).Google Scholar
  34. 34.
    R.E. Anderson, M.B. Maude, S.E.G. Nilsson and K. Narfstrom, Plasma lipid abnormalities in the Abyssinian cat with a hereditary rod-cone degeneration. Exp. Eye Res. 53: 415–417 (1991).PubMedCrossRefGoogle Scholar
  35. 35.
    D. Toussaint and P. Danis, An ocular pathologic study of Refsum’s syndrome. Am. J. Ophthalmol. 72: 342–347 (1971).PubMedGoogle Scholar
  36. 36.
    N.G. Bazan, D.L. Birkle and T.S. Reddy, Biochemical and nutritional aspects of the metabolism of polyunsaturated fatty acids and phospholipids in experimental models of retinal degeneration. In: “Retinal Degenerations: Experimental and Clinical Studies”. R.E. Anderson, J.G. Hollyfield and M.M. LaVail, Eds. Alan R. Liss, Inc., New York (1985).Google Scholar
  37. 37.
    R.W. Mahley and K.H. Weisgraber, Canine lipoproteins and atherosclerosis. I. Isolation and characterisation of plasma lipoproteins from control dogs. Circ. Res. 35: 713–721 (1974).PubMedCrossRefGoogle Scholar
  38. 38.
    C.A. Converse, T. McLachlan, H.M. Hammer, C.J. Packard and J. Shepherd, Hyperlipidaemia in retinitis pigmentosa. In: “Retinal Degenerations: Experimental and Clinical Studies.” R.E. Anderson, J.G. Hollyfield and M.M. LaVail. Eds. Alan R. Liss, Inc. New York (1985).Google Scholar
  39. 39.
    C.E. Jahn, K. Oette, A. Esser, K. V. Bergman and O. Leiss, Increased prevalence of apolipoprotein E2 in patients with Retinitis Pigmentosa. Ophthalmic Res. 19: 285–288 (1987).PubMedCrossRefGoogle Scholar
  40. 40.
    C.A. Converse, H.M. Hammer, C.J. Packard and J. Shepherd, Plasma lipid abnormalities in retinitis pigmentosa and related conditions. Trans. Ophthalmol. Soc. UK 103: 508–512 (1983).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • P. Watson
    • 1
  • A. Wrigstad
    • 2
  • R. C. Riis
    • 3
  • K. Narfstrom
    • 1
    • 4
  • P. G. C. Bedford
    • 1
  • S. E. G. Nilsson
    • 2
  1. 1.Department of Small Animal StudiesRoyal Veterinary CollegeHatfieldUK
  2. 2.Department of OphthalmologyUniversity of LinkopingLinkopingSweden
  3. 3.Comparative Ophthalmology ServiceCollege of Veterinary Medicine. Cornell UniversityIthacaUSA
  4. 4.Department of Surgery and MedicineFaculty of Veterinary Medicine, Swedish University of Agricultural SciencesUppsalaSweden

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