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Genetic Variability of Major Histocompatibility Complex in Human Populations

  • Takashi Gojobori
  • Tadashi Imanishi

Abstract

Human major histocompatibility complex (MHC) molecules are called human leukocyte antigens (HLA), which were discovered in 1958 (Dausset, 1958). A variety of knowledge about HLA structures, functions, and genes have been obtained particularly at the molecular level. The HLA gene complex in human is 4Mbp long and is located on chromosome 6. HLA genes are classified essentially into two groups, class I and class II, depending on their structures and functions (Klein, 1986). Sometimes, complement loci which are also located within the MHC gene region are called as class III. Genes in each class exist as a multigene family in the MHC gene region.

Keywords

Ethnic Group Major Histocompatibility Complex Genetic Distance Human Leukocyte Antigen Major Histocompatibility Complex Class 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bernstein, F.Z., 1930, Fortgesetzte Untersuchungen aus der Theorie der BlutgruppenInd. Abst. Vereb. Lehre 56:233.Google Scholar
  2. Cavalli-Sforza, L.L., Piazza, A., Menozzi, P., and Mountain, J., 1988, Reconstruction of human evolution: Bringing together genetic, Archaeological, and linguistic data Proc. Natl. Acad. Sci. 85:6002–6006.PubMedCrossRefGoogle Scholar
  3. Dausset, J., 1958, Iso-leuco-anticorpsActa Haemotal. 20:156–166.CrossRefGoogle Scholar
  4. Gojobori, T, Imanishi, T., Ina, Y., Saitou, N., Tateno, Y., Sato, K., Takata, H., Kimura, A., Nishimura, Y., Akaza, T., Miyoshi, H., Mura, T., Tokunaga, K., Tanaka, H., Konoeda, Y., Wakisaka, A., Juji, T., Sasazuki, T., Tsuji, K., and Inoko, H., 1992a, Construction of the MHC database, in: “HLA 1991,” Vol.1, Tsuji, K. et al. eds, pp.66–67, Oxford University Press, Oxford.Google Scholar
  5. Gojobori, T, Imanishi, T, and Ina, Y., 1992b, Statistics in the numbers of panels stored in the MHC database in: “HLA 1991,” Vol.1, Tsuji, K. et al., eds., pp.67–76, Oxford University Press, Oxford.Google Scholar
  6. Hughes, A.L., and Nei, M., 1988, Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selectionNature 335:167–170.PubMedCrossRefGoogle Scholar
  7. Hughes, A.L., and Nei, M., 1989, Nucleotide substitution at major histocompatibility complex class II loci: Evidence for overdominance selectionProc. Natl. Acad. Sci. USA 86:958–962.PubMedCrossRefGoogle Scholar
  8. Imanishi, T., Akaza T., Kimura A., Tokunaga K., and Gojobori T., 1992a, Estimation of allele and haplotype frequencies for HLA and complement loci, in: “HLA 1991,” Vol.1, Tsuji, K. et al., eds, pp76–79, Oxford University Press, Oxford.Google Scholar
  9. Imanishi, T., Wakisaka, A., and Gojobori, T., 1992b, Genetic relationships among various human populations indicated by MHC polymorphisms, in: “HLA 1991,” Vol. 1, Tsuji, K. et al., eds, pp.627–632, Oxford University Press, Oxford.Google Scholar
  10. Inoko, H., Sato K., Takano H., Imanishi T., Ina Y., Saitou N., Tateno Y., Kimura A., Nishimura Y., Akaza T., Miyoshi H., Mura T., Tokunaga K., Tanaka H., Konoeda Y., Wakisaka A., Juji T., Sasazuki T., Tsuji K., and Gojobori T., 1992, Data flow from collection of raw data to construction of the MHC database, in: “HLA 1991,” Vol.1, Tsuji K. et.at., eds., p.65, Oxford University Press, Oxford.Google Scholar
  11. Klein, J., 1986, “Natural History of the Major Histocompatibility Complex,” John Wiley & Sons, New York.Google Scholar
  12. Nei, M., 1972, Genetic distance between populationsAmer. Natur. 106:283–292.CrossRefGoogle Scholar
  13. Nei, M., 1975, “Molecular Population Genetics and Evolution,” North-Holland, Amsterdam.Google Scholar
  14. Saitou, N., and Nei, M., 1987, Neighbor-joining method: A new method for reconstructing phylogenetic treesMol. Biol. Evol. 4:406–425.PubMedGoogle Scholar
  15. Sokal, R.R., and Sneath, P.H.A., 1963, “Principles of Numerical Taxonomy,” Freeman, W.H., San Francisco.Google Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Takashi Gojobori
    • 1
  • Tadashi Imanishi
    • 2
  1. 1.DNA Research CenterNational Institute of GeneticsMishima 411Japan
  2. 2.Department of AnthropologyFaculty of Science the University of TokyoTokyo 113Japan

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