Abstract
Researches on tumor transplantation and blood groups simultaneously began at the turn of this century. However, they had nothing in common for the following three decades. The man who eventually brought them together was J.B.S. Haldane (see Klein, 1986; p. 7). In 1933, Haldane made a tour of the United States during which he talked to C.C. Little, then at the Jackson Laboratory in Bar Harbor, about his work on tumor transplantation. In a paper published in Nature Haldane (1933) wrote:
The genetics of reaction to transplantable tumours have been very fully worked out by Little and his colleagues. The laws disclosed are precisely similar to those which govern the transplantation of normal tissue or the transfusion of blood or of leukaemic corpuscles.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Braciale, T.J., Sweetser, M.T., Morrison, L.A., Kittlesen, D.J., and Braciale, V.L., 1989, Class I major histocompatibility complex-restricted cytolytic T lymphocytes recognize a limited number of sites on the influenza hemagglutininProc. Natl. Acad. Sci. USA86:277.
Bjorkman, P.J., Saper, M.A., Samraoui, B., Bennet, W.S., Strominger J.L., and Wiley, D.C., 1987a, Structure of the human class I histocompatibility antigenHLA-A2, Nature329:506.
Bjorkman, P.J., Saper, M.A., Samraoui, B., Bennet, W.S., Strominger, J.L., and Wiley, D.C., 1987b, The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigensNature329:512.
Blackman, M., Kappler, J., and Marrack, P., 1990, The role of the T cell receptor in positive and negative selection of developing T cellsScience248:1335.
Boehmer, H.V., and Kisielow, P., 1990, Self-nonself discrimination by T cells, Science 248:1369–1373.
Bodmer, W.F., 1972, Evolutionary significance of theHLAsystem,Nature237:139.
Carreno, B.M., Anderson, R.W., Coligan, J.E., and Biddison, W.E., 1990HLA-B37and HLA-A2.1molecules bind largely nonoverlapping sets of peptidesProc. Natl. Acad. Sci. USA87:3420.
Chicz, R.M., Urban, R.G., Lane, W.S., Gorga, J.C., Stern, L.J., Vignali, D.A.A., and Strominger, J.L., 1992, Predominant naturally processed peptides bound toHLA-DR1are derived from MHC-related molecules and are heterogeneous in size,Nature358:764.
Clarke, B., 1976, The ecological genetics of host-parasite relationshipsin: “Genetic Aspects of Host-Parasite Relationships,” A.E.R. Taylor and R.M. Muller, eds., Blackwell, Oxford.
Crow, J.F., 1990a, Forewordin: “Selected Genetics Papers of J.B.S. Haldane,” K.R. Dronamraju, ed., Garland, New York & London.
Crow, J.F., 1990b, Mapping functionsGenetics125:669.
Crow, J.F., 1992a, Erwin Schrodinger and the hornless cattle problemGenetics130:237.
Crow, J.F., 1992b, Centennial: J.B.S. Haldane, 1982–1964Genetics130:1.
Damian, R.T., 1964, Molecular mimicry: antigen sharing by parasite and host and its consequencesAm. Nat.98:129.
Damian, R.T., 1987, Molecular mimicry revisitedParasitol. Today3:263.
Denniston, C., and Crow, J.F., 1990, Alternative fitness models with the same allele frequency dynamicsGenetics125:201.
Doherty, P.C., and Zinkernagel, R.M., 1975, Enhanced immunological surveillance in mice heterozygous at theH-2gene complex,Nature256:50.
Falk, K., Rotzschke, O., Stevanovie, S., Jung, G., and Rammensee, H.-G., 1991, Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC moleculesNature351:290.
Guo, H.-C., Jardetzky, T.S., Garrett, T.P.J., Lane, W.S., Strominger, J.L., and Willy, D.C., 1992, Different length peptides bind to HLA-Aw68 similarly at their ends but bulge out in the middleNature360:364.
Haldane, J.B.S., 1933, The genetics of cancerNature132:265.
Haldane, J.B.S., 1949, Disease and evolutionLa ricerca scientifica, supplemento19: 2.
Hamilton, W.D., 1980, Sex versus non-sex versus parasiteOikos35:282.
Hill, S.A., Allsopp, C.E.M., Kwiatkowski, D., Anstey, N.M., Twumasi, P., Rowe, P.A., Bennett, S., Brewster, D., McMichael, A.J., and Greewood, B.M., 1991, Common West African HLA antigens are associated with protection from severemalaria Nature 352:595.
Hood, L.E., Weissman, I.L., Wood, W.B., and Wilson, J.H., 1984, “Immunology,” Benjamin/Cummings, California.
Hughes, A.L., and Nei, M., 1988, Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selectionNature335:167.
Hughes, A.L., and Nei, M., 1989, Nucleotide substitution at major histocompatibility complex class II loci: Evidence for overdominant selectionProc. Natl. Acad.Sci. USA86:958.
Hunt, D.F., Henderson, R.A., Shabanowitz, J., Sakaguchi, K., Michel, H., Sevilir, N., Cox, AL., Appelia, E., and Engelhard, V.H., 1992, Characterization of peptides bound to the class I MHC moleculeHLA-A2.1by mass spectrometry,Science255:1261.
Jardetzky, T.S., Lane, W.S., Robinson, R.A., Madden, D.R., and Wiley, D.C., 1991, Identification of self peptides bound to purified HLA-B27Nature353:326.
Kimura, M., 1968, Evolutionary rate at the molecular levelNature217:624.
Klein, J., 1980, Generation of diversityat MHCloci: Implications for T cell receptor repertories, in: “Immunology 80,” M. Fougereau and J. Dausset, eds., Academic, London.
Klein, J., 1986, “Natural History of the Major Histocompatibility Complex,” John Wiley & Sons, New York.
Klein, J., 1990, “Immunology,” Blackwell, Oxford.
Klein, J., 1991, OfHLAtryps, and selection: An essay on coevolution ofMHC and parasites,Hum. Immunol. 30:247.
Klein, J., Gutknecht, J., and Fischer, N., 1990, The major histocompatibility complex and human evolutionTrends Genet.6:7.
Klein, J., and Takahata, N., 1990, The major histocompatibility complex and the quest for originsImmunol. Rev.113:5.
Klein, J., Satta, Y., O’hUigin, C., and Takahata, N., 1993, The molecular descent of the major histocompatibility complex, Ann.Rev. Immunol.(in press)
Li, W.-H., and Sadler, L.A., 1991, Low nucleotide diversity in manGenetics129:513.
May, R., 1983, Parasitic infections as regulators of animal populationsAmerican Scientist71:36.
Nathenson, S.G., Uehara, H., and Ewenstein, B.W., 1981, Primary structural analysis of the transplantation antigens of the murine H-2 major histocompatibility complexAnn. Rev. Biochem.50:1025.
Nei, M., 1987, “Molecular Evolutionary Genetics,” Columbia University Press, New York.
Nei, M., and Hughes, A.L., 1991, Polymorphism and evolution of the major histocompatibility complex loci in mammals, in: “Evolution at the Molecular Level,” R.K. Selander, A.G. Clark and T.S. Whittam, eds., Sinauer Associates INC. Sunderland, Massachusetts.
Ohno, S., 1991, To be or not to be a responder in T-cell responses: ubiquitous oligopeptides in all proteinsImmunogenetics34:215.
Ohno, S., 1992, “Self” to cytotoxic T cells has to be 1000 or less high affinity nonapeptides per MHC antigenImmunogenetics36:22.
Ramsdell, F., and Fowlkes, B.J., 1990, Clonal deletion versus clonal anergy: The role of the thymus in inducing self toleranceScience248:1342.
Rudensky, A. Yu., Rath, S., Preston-Hurlburt, P., Murphy, D.B., and Janeway Jr., C.A., 1991, On the complexity of selfNature353:660.
Satta, Y., 1992, Balancing selection atHLAloci, in: “Molecular Paleopopulation Biology,” N. Takahata, ed., Japan. Sci. Soc. Press, Tokyo.
Satta, Y., Takahata, N., Schonbach, C., Gutknecht, J., and Klein, J., 1991, Calibrating evolutionary rates at the major histocompatibility complex loci, in: “Molecular Evolution of the Major Histocompatibility Complex,” J. Klein and D. Klein, eds., Springer-Verlag, Heidelberg.
Schild, H., Riitzschke, O., Kalbacher, H., and Rammensee, H.-G., 1990, Limit of T cell tolerance to self proteins by peptide presentationScience247:1587.
Seger, S.W., 1988, Dynamics of some simple host-parasite models with more than two genotypes in each speciesPhil. Trans. R. Soc. Lond. B319:541.
Snell, G.D., 1968, TheH-2locus of the mouse: observations and speculations concerning its comparative genetics and its polymorphism,Folia Biol.14:335.
Sturmbauer, C., and Meyer, A., 1992, Genetic divergence, speciation and morphological stasis in a lineage of African cichlid fishesNature358:578.
Takahama, Y., Shores, E.W., and Singer, A., 1992, Negative selection of precursor thymocytes before their differentiation into CD4+CD8+ cellsScience258:653.
Takahata, N., 1990, A simple genealogical structure of strongly balanced allelic lines and trans-species evolution of polymorphismProc. Natl. Acad. Sci. USA87:2419.
Takahata, N., and Nei, M., 1990, Allelic genealogy under overdominant and frequency-dependent selection and polymorphism of major histocompatibility complex lociGenetics124:967.
Takahata, N., Satta, Y., and Klein, J., 1992a, Trans-species polymorphism of the major histocompatibility complex(Mhc)loci, in: “Progress in Immunology, Vol. 8,” (in press)
Takahata, N., Satta, Y., and Klein, J., 1992b, Polymorphism and balancing selection at major histocompatibility complex lociGenetics130:925.
Wada, K., Wada, Y., Ishibashi, F., Gojobori, T., Ikemura, T., 1992, Codon usage tabulated from the GenBank genetic sequence dataNucl. Acids Res. Suppl.20:2111.
Wills, C., 1991, Maintenance of multiallelic polymorphism at theMHCregion,Immunol. Rev.124:165.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer Science+Business Media New York
About this chapter
Cite this chapter
Takahata, N. (1993). Haldane’s Contributions to the Understanding of the Evolution of Vertebrate Immune System. In: Majumder, P.P. (eds) Human Population Genetics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2970-5_4
Download citation
DOI: https://doi.org/10.1007/978-1-4615-2970-5_4
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6292-0
Online ISBN: 978-1-4615-2970-5
eBook Packages: Springer Book Archive