Evidence for Glucose Uptake in the Rabbit Carotid Body
The carotid body located in the bifurcation of the carotid arteries is able to detect gas changes in blood composition (PO2, PCO2/pH) and to transduce them into afferent nerve signal. The intimate mechanism responsible for this chemoreceptive response to PO2 changes is not yet well understood. Various reports point to a chain of events initiated by disturbance of cell metabolism followed by transmitter release and depolarization of nerve endings (Mills and Jobsis, 1972; Hayashida et al., 1980). It seems, however, that glycolysis also plays an essential role in chemoreception, because lowering PO2 stimulates glycolysis in the cat carotid body in vitro (Delpiano and Acker, 1985). The aim of this article is to present evidence that this may not be the case as inhibition of glucose utilization by substrate deprivation or by uptake blocks almost totally glycolyticdependent pH decrease but only partially chemoreception.
KeywordsCarotid Body Nerve Response Nerve Discharge Sensory Nerve Response Tissue Acidification
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