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Differentiating Agents and Cancer Therapy. Role of Cellular Lipid Peroxidation and its Product 4-Hydroxynonenal in the Control of Cell Proliferation and Differentiation

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Combination Therapies 2

Abstract

Numerous experimental observations provide evidences that malignancy can be reversed by causing cancerous cells to differentiate and stop growing (1–5). This statement implies that transformation does not inevitably destroy the inherent potential for expression, under appropriate environmental conditions, of differentiated characteristics.

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Authors and Affiliations

  1. Institute of Experimental Medicine, CNR, Rome, Italy

    Vito M. Fazio, Monica Rinaldi & Maria Giulia Farace

  2. Dept. of Experimental Medicine and Oncology, University of Torino, Italy

    Giuseppina Barrera, Roberto Muraca & Mario U. Dianzani

  3. Dept. of Exp. Medicine and Biochemical Sciences, “Tor Vergata” University, Rome, Italy

    Silvia A. Ciafrè & Maria Giulia Farace

  4. Dept. of Surgery, “Tor Vergata” University, Rome, Italy

    Marzia Lazzari

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  1. Vito M. Fazio
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  1. University of Rome “Tor Vergata”, Rome, Italy

    Enrico Garaci

  2. The Institute for Advanced Studies in Immunology and Aging, Washington, D.C., USA

    Allan L. Goldstein

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Fazio, V.M. et al. (1993). Differentiating Agents and Cancer Therapy. Role of Cellular Lipid Peroxidation and its Product 4-Hydroxynonenal in the Control of Cell Proliferation and Differentiation. In: Garaci, E., Goldstein, A.L. (eds) Combination Therapies 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2964-4_13

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