Point Mutations in the Dihydropteroate Synthase Gene Causing Sulfonamide Resistance
Sulfonamides act by competing with p-aminobenzoic acid (PABA) in the formation of dihydropteroate by the enzyme dihydropteroate synthase1. In many bacteria, as well as protozooans and fungi, this inhibition leads to a block in the synthesis of dihydrofolate, and eventually to a stop in DNA synthesis due to lack of dTTP.
KeywordsFolate Ampicillin dTTP Dihydrofolate Pteridine
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