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Point Mutations in the Dihydropteroate Synthase Gene Causing Sulfonamide Resistance

  • Göte Swedberg
  • Christian Fermér
  • Ola Sköld
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 338)

Abstract

Sulfonamides act by competing with p-aminobenzoic acid (PABA) in the formation of dihydropteroate by the enzyme dihydropteroate synthase1. In many bacteria, as well as protozooans and fungi, this inhibition leads to a block in the synthesis of dihydrofolate, and eventually to a stop in DNA synthesis due to lack of dTTP.

Keywords

Resistant Strain Amino Acid Change Sensitive Strain Neisseria Meningitidis Amino Acid Difference 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Göte Swedberg
    • 1
  • Christian Fermér
    • 1
  • Ola Sköld
    • 1
  1. 1.Department of Biological Sciences, Division of Microbiology, Biomedical centreUppsala UniversityUppsalaSweden

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