Advertisement

The Chemokines pp 205-205 | Cite as

Plasma Interleukin 8 Levels in Patients with Septic Shock

  • K. Inada
  • S. Endo
  • T. Takakuwa
  • A. Yamada
  • Y. Kuwata
  • S. Hoshi
  • H. Yamashita
  • M. Yoshida
  • M. Ceska
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 351)

Abstract

IL-8, polymorphonuclear leukocyte elastase (PMNE) and endotoxin at the development of septic shock were measured. IL-8 and PMNE were measured by ELISA. Endotoxin level was measured by endotoxin-specific Endospecy test (Seikagaku Corporation, Ltd., Tokyo). The pre-procedure of the plasma was carried out by using new PCA method developed by us. Its normal level was less than 9.8 pg/ml. IL-8 level at the development of the septic shock was 6.28 ± 9.00 ng/ml (mean ± SD, n=29), and significantly higher (p<0.001) than 0.35 ± 0.35 ng/ml (n=40) in the sepsis without shock. IL-8 level in volunteers was less than measurable limit. The significant correlation was observed between IL-8 and PMNE levels at the development of septic shock (r=0.6916, p<0.001). No correlation was observed between endotoxin and IL-8 levels at the development of septic shock (r=0.1839, p=0.3395). It was suggested that IL-8 may be related to the production of PMNE at the septic shock, and substances except for endotoxin may also be related to the stimulation of the production of IL-8.

Keywords

Septic Shock Normal Level Synovial Fluid Polymorphonuclear Leukocyte Measurable Limit 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • K. Inada
    • 1
  • S. Endo
    • 2
  • T. Takakuwa
    • 2
  • A. Yamada
    • 2
  • Y. Kuwata
    • 2
  • S. Hoshi
    • 2
  • H. Yamashita
    • 1
  • M. Yoshida
    • 1
  • M. Ceska
    • 3
  1. 1.Department of BacteriologyIwate Medical UniversityMoriokaJapan
  2. 2.Critical Care and Emergency CenterMoriokaJapan
  3. 3.Sandoz Research InstituteViennaAustria

Personalised recommendations