The Chemokines pp 205-205 | Cite as

Plasma Interleukin 8 Levels in Patients with Septic Shock

  • K. Inada
  • S. Endo
  • T. Takakuwa
  • A. Yamada
  • Y. Kuwata
  • S. Hoshi
  • H. Yamashita
  • M. Yoshida
  • M. Ceska
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 351)

Abstract

IL-8, polymorphonuclear leukocyte elastase (PMNE) and endotoxin at the development of septic shock were measured. IL-8 and PMNE were measured by ELISA. Endotoxin level was measured by endotoxin-specific Endospecy test (Seikagaku Corporation, Ltd., Tokyo). The pre-procedure of the plasma was carried out by using new PCA method developed by us. Its normal level was less than 9.8 pg/ml. IL-8 level at the development of the septic shock was 6.28 ± 9.00 ng/ml (mean ± SD, n=29), and significantly higher (p<0.001) than 0.35 ± 0.35 ng/ml (n=40) in the sepsis without shock. IL-8 level in volunteers was less than measurable limit. The significant correlation was observed between IL-8 and PMNE levels at the development of septic shock (r=0.6916, p<0.001). No correlation was observed between endotoxin and IL-8 levels at the development of septic shock (r=0.1839, p=0.3395). It was suggested that IL-8 may be related to the production of PMNE at the septic shock, and substances except for endotoxin may also be related to the stimulation of the production of IL-8.

Keywords

Arthritis Mesilate Nafamostat 

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • K. Inada
    • 1
  • S. Endo
    • 2
  • T. Takakuwa
    • 2
  • A. Yamada
    • 2
  • Y. Kuwata
    • 2
  • S. Hoshi
    • 2
  • H. Yamashita
    • 1
  • M. Yoshida
    • 1
  • M. Ceska
    • 3
  1. 1.Department of BacteriologyIwate Medical UniversityMoriokaJapan
  2. 2.Critical Care and Emergency CenterMoriokaJapan
  3. 3.Sandoz Research InstituteViennaAustria

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