Abstract
Interleukin 8 (IL-8) is a cytokine known as a potent neutrophil activator. Neutrophil elastase (NE) is released by activated neutrophil. In this study, we tried to examine serial changes in serum immunoreactive IL-8 and NE after major surgeries and elucidate the interaction between cytokine response and surgical trauma. We studied 10 patients undergoing radical surgery against thoracic esophageal cancer, 5 patients undergoing elective total gastrectomy and 3 patients suffering from severe acute pancreatitis. Serum IL-8 levels were determined by EIA and plasma NE levels were also determined by EIA. Furthermore we also examined serum IL-6 levels in these patients simultaneously as an index of severity of surgical trauma (1).
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References
Murata, A., et al. 1990 Immunol. Invest. 19: 271–278.
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© 1993 Springer Science+Business Media New York
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Murata, A., Toda, H., Matsuura, N., Oka, Y., Mori, T. (1993). Serial Changes in Circulating Interleukin-8 and Neutrophil Elastase after Major Surgery. In: Lindley, I.J.D., Westwick, J., Kunkel, S. (eds) The Chemokines. Advances in Experimental Medicine and Biology, vol 351. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2952-1_45
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DOI: https://doi.org/10.1007/978-1-4615-2952-1_45
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