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The Chemokines pp 139–146Cite as

The Effects of Human Recombinant MIP-1α, MIP-1β, and Rantes on the Chemotaxis and Adhesion of T Cell Subsets

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 351))

Abstract

Different members of the chemokine superfamily chemoattract and activate specific leukocyte subsets. For example, IL-8 predominantly chemoattracts neutrophils in vivo, while MCAF is selectively chemotactic for monocytes and induces the accumulation of monocytes in vivo (1). Some of these chemokines can also induce enzyme release, intracellular calcium flux, shape change and alterations in adhesiveness to an endothelial monolayer in neutrophils and monocytes (1-5). The directional migration of lymphocytes into inflamed tissues is presumeably also mediated by a variety of chemotactic molecules. The role of cytokines in the regulation of T cell adhesion and chemotaxis is presently unknown. We have explored the biological activity of the available chemokines on T lymphocyte function. In this report, we will describe our recent studies demonstrating the effects of recombinant human MIP-lα, MIP-1β, and RANTES on T cell chemotaxis and adhesion to human endothelial cells.

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Author information

Authors and Affiliations

  1. Division of Cancer Research, Laboratory of Molecular Immunoregulation Biological Response Modifiers Program, NCI-FCRDC, Frederick, MD, 21702, USA

    Dennis D. Taub, Andrew R. Lloyd, Ji-Ming Wang, Joost J. Oppenheim & David J. Kelvin

Authors
  1. Dennis D. Taub
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  2. Andrew R. Lloyd
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  3. Ji-Ming Wang
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  4. Joost J. Oppenheim
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  5. David J. Kelvin
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Editor information

Editors and Affiliations

  1. Sandoz Research Institute, Vienna, Austria

    I. J. D. Lindley

  2. University of Bath, Bath, UK

    J. Westwick

  3. University of Michigan, Ann Arbor, Michigan, USA

    S. Kunkel

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© 1993 Springer Science+Business Media New York

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Taub, D.D., Lloyd, A.R., Wang, JM., Oppenheim, J.J., Kelvin, D.J. (1993). The Effects of Human Recombinant MIP-1α, MIP-1β, and Rantes on the Chemotaxis and Adhesion of T Cell Subsets. In: Lindley, I.J.D., Westwick, J., Kunkel, S. (eds) The Chemokines. Advances in Experimental Medicine and Biology, vol 351. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2952-1_15

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  • DOI: https://doi.org/10.1007/978-1-4615-2952-1_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6283-8

  • Online ISBN: 978-1-4615-2952-1

  • eBook Packages: Springer Book Archive

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