The Chemokines

Volume 351 of the series Advances in Experimental Medicine and Biology pp 1-11

Chemotactic and Inflammatory Cytokines — CXC and CC Proteins

  • Marco BaggioliniAffiliated withTheodor-Kocher Institute, University of Bern

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This is the third meeting in about three years on a family of cytokines that became fancy with the discovery of interleukin-8 (IL-8). The IL-8-related cytokines are small, and relatively easy to work with. They are characterized by four conserved cysteine residues. Alignment of these residues differentiates two subfamilies: one with the first two cysteines separated by one amino acid (CXC cytokines), and the other with adjacent cysteines (CC cytokines). The genes for the two clans inhabit different chromosomes, number 4 for the CXC and number 17 for the CC, and the cytokines that they produce have different target cell preferences.