Significance of Virulence Factors and Immuno-Evasion for the Design of Gene-Deleted Herpesvirus Marker Vaccines
The family, HERPESVIRIDAE, consists of over 100 virus species that cause disease in animals from fish to man (Herpesvirus Study Group, 1992). This morning I will describe vaccines for two of these herpesviruses, namely, swine pseudorabies virus (PRV; Aujeszky’s disease virus) and infectious bovine rhinotracheitis virus (IBRV; bovine herpesvirus-1). PRV and IBRV cause economically important diseases affecting the respiratory, reproductive and central nervous systems of the 500 million pigs and 1.28 billion cattle worldwide. PRV and IBRV also induce abortions in pregnant animals and lethal infections of newborn.
KeywordsMaternal Antibody Pseudorabies Virus Thymidine Kinase Gene Glycoprotein Gene Marker Vaccine
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