Targeting Proteins to Antigen-Presenting Cells and Induction of Cytokines as a Basis for Adjuvant Activity
The need for improved and new vaccines is evident. While live virus vaccines have been very useful, they can produce severed infections in persons whose immune systems are compromised because of congenital deficiency, malnutrition or infections (notably HIV). If subunit antigens can elicit equivalent protection they are preferred. Preparation of antigens by recombinant technology has opened up the possibility of a new generation of vaccines, but a safe and efficacious adjuvant is a necessary component. The only adjuvant approved for human use is aluminum hydroxide or phosphate. While alum is an effective adjuvant for bacterial toxoids it has limited efficacy in other situations, for reasons that will be discussed below.
KeywordsSimian Immunodeficiency Virus Genital Herpes Adjuvant Arthritis Adjuvant Activity IgG2a Antibody
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