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The Mammalian Cochlear Nuclei pp 19–28Cite as

Cell Birth, Formation of Efferent Connections, and Establishment of Tonotopic Order in the Rat Cochlear Nucleus

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Part of the book series: NATO ASI series ((NSSA,volume 239))

Abstract

The development of the cochlear nucleus (CN) involves proliferation of cells, migration of postmitotic neuroblasts to their final destinations, neurite outgrowth, synapse formation, and cell death. Ultimately, these events lead to the establishment of the high degree of topographic organization observed in the adult. The auditory system of rats is immature at birth which makes this species preferable for developmental studies. Physiological hearing in rats begins about two weeks after birth. The outer ear canals do not open before postnatal day 12 (P12), and first auditory brainstem responses can be reliably recorded at P12–P14 (Jewett and Romano,’ 72; Tokimoto et al.,’ 77; Blatchley et al.,’ 87). Since gestation in rats lasts 22 days (i.e. birth usually occurs at embryonic day 22, E22 = PO), there is a period of several weeks until the onset of hearing occurs, during which the above mentioned major developmental events must take place.

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Authors and Affiliations

  1. Department of Animal Physiology, University of Tübingen, Auf der Morgenstelle 28, D-7400, Tübingen 1, Federal Republic of Germany

    Eckhard Friauf & Karl Kandler

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  1. Eckhard Friauf
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  2. Karl Kandler
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Editors and Affiliations

  1. University of Salamanca, Salamanca, Spain

    Miguel A. Merchán

  2. University of Alicante, Alicante, Spain

    José M. Juiz

  3. Medical College of Ohio, Toledo, Ohio, USA

    Donald A. Godfrey

  4. University of Connecticut, Storrs, Connecticut, USA

    Enrico Mugnaini

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© 1993 Springer Science+Business Media New York

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Friauf, E., Kandler, K. (1993). Cell Birth, Formation of Efferent Connections, and Establishment of Tonotopic Order in the Rat Cochlear Nucleus. In: Merchán, M.A., Juiz, J.M., Godfrey, D.A., Mugnaini, E. (eds) The Mammalian Cochlear Nuclei. NATO ASI series, vol 239. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2932-3_2

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  • DOI: https://doi.org/10.1007/978-1-4615-2932-3_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6273-9

  • Online ISBN: 978-1-4615-2932-3

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