Glycine and GABA: Transmitter Candidates of Projections Descending to the Cochlear Nucleus
Acoustic information, encoded in the cochlea and conveyed to the cochlear nucleus (CN) by cochlear nerve fibers, is processed by cell groups in the CN. Inhibitory neurotransmission appears to play a prominent role at this level of auditory processing (Brugge and Geisler,’ 78; Voight and Young,’ 80; Caspary et al., this volume). Information has been emerging recently with regard to the location and transmitters of the inhibitory neurons which synapse in the CN. These neurons may originate in other brain stem nuclei that project to the CN, or could lie within the CN itself (Saint Marie et al.,’ 91, this volume; Oertel and Wickesberg, this volume). These inhibitory projections probably use the amino acid transmitters, glycine and GABA at their synapses in the CN (Whitfield and Comis,’ 66; Tachibana and Kuriyama,’ 74; Fex and Wenthold,’ 76; Fisher and Davies,’ 76; Godfrey et al,’ 77,’ 78; Caspary et al,’ 79; Wenthold,’ 79; Martin et al,’ 82).
KeywordsCochlear Nucleus Dorsal Cochlear Nucleus Superior Olivary Complex Trapezoid Body Amino Acid Transmitter
Unable to display preview. Download preview PDF.
- Blasberg, R.G., 1968, Specificity of cerebral amino acid transport: A kinetic analysis, in: “Progress in Brain Research, Vol. 29”, Lajtha A. and Ford D.H., eds., pp. 245–256, Elsevier, Amsterdam.Google Scholar
- Cuenod, M., Bagnoli, P., Beaudet, A., Rustioni, A., Wiklund, L. and Streit, P., 1982, Transmitter-specific retrograde labelling of neurons, in: “Cytochemical Methods in Neuroanatomy”, Chan-Palay V. and Palay S.L., eds., A.R. Liss, Inc., New York, pp. 17–44.Google Scholar
- Hökfelt, T. and Ljungdahl, A., 1975, Uptake mechanisms as a basis for the histochemical identification and tracing of transmitter-specific neuron populations, in: “The use of axonal transport for studies of neuronal connectivity”, Cowan W.M. and Cuenod M., eds., Elsevier, Amsterdam, pp. 249–305.Google Scholar
- Iversen, L.L., 1978, Identification of transmitter-speeifie neurons in the CNS by autoradiography, in: “Handbook of Psychopharmacology, Vol. 9”, Iversen L.L., Iversen S.D. and Snyder S.H., eds., Plenum Press, New York, pp. 41–68.Google Scholar
- Lajtha, A., 1967, Transport as control mechanism of cerebral metabolite levels, in: “Progress in Brain Research, Vol. 29”, Lajtha A. and Ford D. H., eds., Elsevier, Amsterdam, pp. 201–216.Google Scholar
- Rasmussen, G.L., 1967, Efferent connections of the cochlear nucleus, in: “Sensorineural Hearing Processes and Disorders”, Graham A. B., ed., Little Brown, Boston, pp. 61–75.Google Scholar
- van Noort, J., 1969, The anatomical basis for frequency analysis in the cochlear nucleus complex, Psychiat. Neurolg. Neurochir., 72:109–114.Google Scholar
- Voight, H.F. and Young, E.D., 1980, Evidence of inhibitory interactions between neurons in dorsal cochlear nucleus, J. Neurophysiol., 44:76–96.Google Scholar
- Wenthold, R.J., Betz, H., Reeks, K.A., Parakkal, M.H. and Altschuler, R.A., 1985, Localization of glycinergic synapses in the cochlear nucleus and superior olivary complex with monoclonal antibodies specific for the glycine receptor, Neurosci. Abstr., 11:1048.Google Scholar
- Whitfield, I.C. and Comis, S.D., 1966, The role of inhibition in information transfer: The interaction of centrifugal and centripetal stimulation on neurones of the cochlear nucleus, “Final report II AF EOAR” (U.S. Air Force), 63-115.Google Scholar
- Wiederhold, M.L., 1986, Physiology of the olivocochlear system, in: “Neurobiology of Hearing: The Cochlea”, Altschuler, R.A., Hoffman, D.W. and Bobbin, R.P., eds., Raven Press, New York, pp. 349–370.Google Scholar
- Young, A.B. and MacDonald, R.L., 1983, Glycine as a spinal cord neurotransmitter, in: “Handbook of the spinal cord”, Davidoff R.A., ed,, Marcel Decker, New York, pp. 1–43.Google Scholar