Skip to main content

The Cellular Basis for Signal Processing in the Mammalian Cochlear Nuclei

  • Chapter
The Mammalian Cochlear Nuclei

Part of the book series: NATO ASI series ((NSSA,volume 239))

Abstract

Ramón y Cajal taught us that information in the central nervous system is differentiated and transmitted between individual nerve cells. Lorente de Nó taught us that the cells in the CNS are individuals with unique personalities, which depend on the exact arrangement of the synaptic contacts on their dendrites and the precise distributions of their axons, all of their branches and synaptic endings. In fact Lorente de Nó (’43) emphasized the axonal branching pattern as a criterion for distinguishing neurons.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Arle, J.E. and Kim, D.O., 1991a, Neural modeling of intrinsic and spike-discharge properties of cochlear nucleus neurons, Biol. Cybernetics, 64:273–283.

    Article  CAS  Google Scholar 

  • Arie, J.E. and Kim, D.O., 1991b, Simulations of cochlear nucleus neural circuitry:excitatory-inhibitory response-area types I-IV, J. Acoust. Soc. Amer., 90:3106–3121.

    Article  Google Scholar 

  • Bettler, B., Boulter, B., Hermans-Borgmeyer, I., O’Shea-Greenfield, A., Deneris, E., Moll, C., Borgemeyer, U., Hollmann, J., and Heinemann, S., 1990, Cloning of a novel glutamate receptor subunit, GluR5: expression in the nervous system during development, Neuron, 5:583–595.

    Article  PubMed  CAS  Google Scholar 

  • Boulter, J., Hollmann, M., O’Shea-Greenfield, A., Hartley, M., Deneris, E., Marion, C., and Heinemann, S., 1990, Molecular cloning and functional expression of glutamate receptor subunit genes, Science, 249:1033–1036.

    Article  PubMed  CAS  Google Scholar 

  • Brawer, J., Morest, D.K., and Kane, E., 1974, The neuronal architecture of the cochlear nucleus of the cat, J. Comp. Neurol., 155:251–300.

    Article  PubMed  CAS  Google Scholar 

  • Cohen, E.S., Brawer, J.R., and Morest, D.K., 1972, Projections of the cochlea to the dorsal cochlear nucleus in the cat, Exp. Neurol., 35:470–479.

    Article  PubMed  CAS  Google Scholar 

  • Egeberg, J., Bettler, B., Hermans-Borgmeyer, I., and Heinemann, S., 1991, Cloning of a cDNA for a glutamate receptor subunit activated by kainate but not AMPA, Nature, 361:745–748.

    Article  Google Scholar 

  • Feng, J., 1989, The Coding of Sound in the Cochlear Nucleus: Mechanisms Underlying the Generation of Response Patterns by Different Morphological Cell Types. Doctoral Dissertation. The University of Connecticut, Farmington.

    Google Scholar 

  • Feng, J., Ostapoff, E.-M., Kuwada, S., and Morest, D.K., 1988, Synaptic and membrane properties shape response patterns of neurons in the gerbil cochlear nucleus, Soc. Neurosci. Abstr., 14:490.

    Google Scholar 

  • Glendenning K.K., Hutson, K.A., Nudo, R.J., Masterton, R.B., 1985, Acoustic chiasm II: Anatomical basis of binaurality in lateral superior olive of cat, J. Comp. Neurol., 232:261–285.

    Article  PubMed  CAS  Google Scholar 

  • Godfrey, D.A., Kiang, N.Y.S., and Norris, B.E., 1975a, Single unit activity in the posteroventral cochlear nucleus of the cat, J. Comp. Neurol., 162:247–268.

    Article  PubMed  CAS  Google Scholar 

  • Godfrey, D.A., Kiang, N.Y.S., and Norris, B.E. (1975b) Single unit activity in the dorsal cochlear nucleus of the cat. J. Comp. Neurol., 162:269–284.

    Article  PubMed  CAS  Google Scholar 

  • Hackney, C.M., Osen, K.K., and Kolston, J. 1990, Anatomy of the cochlear nuclear complex of guinea pig, Anat. Embryol., 182:123–149.

    Article  PubMed  CAS  Google Scholar 

  • Hunt, S. and Schmidt, J., 1978, Some observations on the binding patterns of ?-bungarotoxin in the central nervous system of the rat, Brain Res., 157:213–232.

    Article  PubMed  CAS  Google Scholar 

  • Hollmann, M., Hartley, M., and Heinemann, S., 1991, Ca2+ permeability of KA-AMPA-gated glutamate receptor channels depends on subunit composition, Science, 252:851–853.

    Article  PubMed  CAS  Google Scholar 

  • Hollman, M., O’Shea-Greenfield, A., Rogers, S.W., and Heinemann, S., 1989, Cloning by functional expression of a member of the glutamate receptor family, Nature, 342:643–648.

    Article  Google Scholar 

  • Jones, D.R., Hutson, K.A., and Morest, D.K., 1992, Growth cones and structural variation of synaptic end-bulbs in the cochlear nucleus of the adult cat brain, Synapse, 10:291–309.

    Article  PubMed  CAS  Google Scholar 

  • Kane, E.S.C., 1973, Octopus cells in the cochlear nucleus of the cat: heterotypic synapses upon homeotypic neurons, Int. J. Neurosci., 5:251–279.

    Article  PubMed  CAS  Google Scholar 

  • Kane, E.S., 1974a, Synaptic organization in the dorsal cochlear nucleus of the cat: a light and electron microscopic study, J. Comp. Neurol., 155:301–330.

    Article  PubMed  CAS  Google Scholar 

  • Kane, E.S., 1974b, Patterns of degeneration in the caudal cochlear nucleus of the cat after cochlear ablation, Anat. Rec., 179:67–92.

    Article  PubMed  CAS  Google Scholar 

  • Keinanen, K., Wisden, W., Sommer, B., Werner, P., Herb, A., Verdoorn, T.A., Sakman, B., and Seeberg, P.H., 1990, A family of AMPA-selective glutamate receptors, Science, 249:556–560.

    Article  PubMed  CAS  Google Scholar 

  • Kiang, N.Y.S., Morest, D.K., Godfrey, D.A., Guinan, J.J. Jr., and Kane, E.C., 1973, Stimulus coding at caudal levels of the cat’s auditory nervous system. I. Response characteristics of single units, in: “Basic Mechanisms in Hearing”, A. Møller, ed., Academic Press, New York, pp. 455–478.

    Chapter  Google Scholar 

  • Lorente de Nó, R., 1933a, Anatomy of the eighth nerve. The central projection of the nerve endings of the internal ear, Laryngoscope, 43:1–38.

    Google Scholar 

  • Lorente de Nó, R., 1933b, Anatomy of the eighth nerve. III. General plan of structure of the primary cochlear nuclei, Laryngoscope, 43:327–350.

    Google Scholar 

  • Lorente de Nó, R., 1943, Cerebral cortex: architecture, intracortical connections, motor projections, in: “Physiology of the Nervous System. 2nd ed.”, J.F. Fulton, Oxford University Press, London, p. 274–301.

    Google Scholar 

  • Lorente de Nó, R., 1981, “The Primary Acoustic Nuclei”, Raven, New York.

    Google Scholar 

  • Morest, D.K., 1983, Book Review: R. Lorente de Nó, “The Primary Acoustic Nuclei”, New York, Raven, 1981, Ann. Otol. Rhinol. Larngol., 92:212–213.

    Google Scholar 

  • Morest, D.K., and Bohne, B.A., 1983, Noise-induced degeneration in the brain and representation of inner and outer hair cells, Hearing Res., 9:145–151.

    Article  CAS  Google Scholar 

  • Morest, D.K., Hutson, K.A., and Kwok, S. 1990, Cytoarchitectonic atlas of the cochlear nucleus of the Chinchilla, Chinchilla laniger, J. Comp. Neurol., 300:230–248.

    Article  PubMed  CAS  Google Scholar 

  • Morest, D., Jones, D.R., Kwok, S., Ard, M.D., Bohne, B., Yurgelun-Todd, D.A., 1987, Response of the brain to acoustic damage of the cochlea, Assoc. Res. Otolaryngol. Abstr., 10:3–4.

    Google Scholar 

  • Morest, D.K., Kiang, N.Y.S., Kane, E.C., Guiñan, J.J. Jr., and Godfrey, D.A., 1973, Stimulus coding at caudal levels of the cat’s auditory nervous system. II. Patterns of synaptic organization, in: “Basic Mechanisms in Hearing”, A. Møller, ed., Academic Press, New York, pp. 479–504.

    Chapter  Google Scholar 

  • Nakanishi, N.A., Schneider, R., and Axel, R. 1990, A family of glutamate receptor genes — evidence for the formation of heteromultimeric receptors with distinct channel properties, Neuron, 5:569–581.

    Article  PubMed  CAS  Google Scholar 

  • Oertel, D., Wu, S.H., Garb, M.W., and Dizack, C. 1990, Morphology and physiology of cells in slice preparations of the posteroventral cochlear nucleus of mice, J. Comp. Neurol., 295:136–154.

    Article  PubMed  CAS  Google Scholar 

  • Osen, K., 1969, Cytoarchitecture of the cochlear nuclei in the cat, J. Comp. Neurol., 136:453–484.

    Article  PubMed  CAS  Google Scholar 

  • Ostapoff, E.-M., and Morest, D.K., 1991, Synaptic organization of globular bushy cells in the ventral cochlear nucleus of the cat: a quantitative study, J. Comp. Neurol., 314:598–613.

    Article  PubMed  CAS  Google Scholar 

  • Pont, R.I., and Damper, M., 1991, A computational model of afferent neural circuitry from the cochlear to the dorsal acoustic stria, J. Acoust. Soc. Amer., 89:1213–1228.

    Article  CAS  Google Scholar 

  • Rasmussen, G.L., 1967, Efferent connections of the cochlear nucleus, in: “Sensorineural Hearing Processes and Disorders”, A.B. Graham, ed., Little, Brown, Boston, p. 61–75.

    Google Scholar 

  • Rasmussen, G.L., Gacek, R.R., McCrane, E.P., and Baker, C.C., 1960, Model of cochlear nucleus (cat) displaying its afferent and efferent connections, Anat. Rec., 136:344 (cited by Lorente de Nó,’ 81; model currently housed in the laboratory of D. Kent Morest, Farming ton, CT).

    Google Scholar 

  • Rhode, W.A., Oertel, D., and Smith, P.H., 1983, Physiological response properties of cells labelled intracellularly with horseradish peroxidase in cat ventral cochlear nucleus, J. Comp. Neurol., 213:448–463.

    Article  PubMed  CAS  Google Scholar 

  • Rhode, W.S., and Smith, P.H., 1986, Encoding timing and intensity in the ventral cochlear nucleus of the cat, J. Neurophysiol., 56:287–307.

    PubMed  CAS  Google Scholar 

  • Ritz, L.A., and Brownell, W.E., 1982, Single unit analysis of the posteroventral cochlear nucleus of the decerebrate cat, Neuroscience, 7:1995–2010.

    Article  PubMed  CAS  Google Scholar 

  • Rose, J.E., Galambos, R., and Hughes, J.R., 1960, Organization of frequency sensitive neurons in the cochlear nuclear complex of the cat, in: “Neural Mechanisms of the Auditory and Vestibular Systems”, G.L. Rasmussen and W.F. Windle, eds., Thomas, Springfield, p. 116–136.

    Google Scholar 

  • Saint Marie, R.L., Ostapoff, E.-M., Morest, D.K., Wenthold, R.J., 1989, Glycine-immunoreactive projection of the cat lateral superior olive: possible role in midbrain ear dominance, J. Comp. Neurol., 279:382–396.

    Article  PubMed  CAS  Google Scholar 

  • Smith, P.H. and Rhode, W.S., 1989, Structural and functional properties distinguish two types of multipolar cells in the ventral cochlear nucleus, J. Comp. Neurol., 282:595–616.

    Article  PubMed  CAS  Google Scholar 

  • Wada, E., Wada, K., Boutler, J., Deneris, E., Heineman, S., Patrick, J., and Swanson, L.W., 1989, Distribution of alpha 2, alpha 3, alpha 4, and beta 2 neuronal nicotinic receptor subunit mRNAs in the central nervous system: a hydridization histochemical study in the rat, J., Comp. Neurol., 284:314–335.

    Article  CAS  Google Scholar 

  • Wouterlood, F.G., Mugnaini, E., Osen, K.K., and Dahl, A.L., 1984, Stellate neurons in rat dorsal cochlear nucleus studied with combined Golgi impregnation and electron microscopy: synaptic connections and mutual coupling by gap junctions, J. Neurocytol., 13:639–664.

    Article  PubMed  CAS  Google Scholar 

  • Wu, S.H., and Oertel, D., 1984, Intracellular injection with horseradish peroxidase of physiologically characterized stellate and bushy cells in slices of mouse anteroventral cochlear nucleus, J. Neurosci., 4:1577–1588.

    PubMed  CAS  Google Scholar 

  • Young, E.D., Shomer, W.P., White, J.A., Robert, J.M., and Voigt, H.F., 1988, Response properties of cochlear nucleus neurons in relationship to physiological mechanisms, in: “Auditory Function: Neurobiological Bases of Hearing”, Edelman et al., eds, Wiley, New York, pp. 277–312.

    Google Scholar 

  • Young, E.D., and Voigt, H.F., 1982, Response properties of type II and type III units in dorsal cochlear nucleus, Hearing Res., 6:153–169.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer Science+Business Media New York

About this chapter

Cite this chapter

Morest, D.K. (1993). The Cellular Basis for Signal Processing in the Mammalian Cochlear Nuclei. In: Merchán, M.A., Juiz, J.M., Godfrey, D.A., Mugnaini, E. (eds) The Mammalian Cochlear Nuclei. NATO ASI series, vol 239. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2932-3_1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-2932-3_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6273-9

  • Online ISBN: 978-1-4615-2932-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics