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Differential Uptake and Trapping of TI-2 Antigens: an Unexpected Role for Follicular Dendritic Cells in the Induction of TI-2 Immune Responses

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Dendritic Cells in Fundamental and Clinical Immunology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 329))

Abstract

The spleen plays an important role in the protection against capsulated microorganisms e.g. Streptococcus pneumoniae, Neisseria meningitides and Haemophilus influenzae 1. The protective immune response against these micro-organisms is directed mainly against the polysaccharide component of the bacterial capsule, classified as a TI-2 antigen2. Following splenectomy patients are at high risk for fulminant infections due to these bacteria. The presence of the spleen seems to be important in the primary encounter of the antigen, whereas secondary humoral immune responses can also be evoked at sites outside the spleen3. This has led to the suggestion that in the spleen, specific subsets of B cells may be present or that the splenic micro-environment as such may be crucial for the response of B cells to TI-2 antigens. In particular the marginal zone macrophages of the spleen have received much interest in this respect. These macrophages, which take up and retain carbohydrate macromolecules such as TNP-Ficoll/FITC-Ficoll (model TI-2 antigens), have been suggested to play a role in the processing and presentation of TI-2 antigens4-7. However, recent in vivo modulation studies demonstrated that marginal zone macrophages are not required in humoral immune responses against TI-2 antigens8-10.

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Authors and Affiliations

  1. Department of Immunology and Medical Microbiology, TNO Medical Biological Laboratory, 45, 2280, AA, Rijswijk, The Netherlands

    A. J. M. Van den Eertwegh, M. M. Schellekens, W. J. A. Boersma & E. Claassen

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  1. A. J. M. Van den Eertwegh
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  2. M. M. Schellekens
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  3. W. J. A. Boersma
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  4. E. Claassen
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Editors and Affiliations

  1. Vrije Universiteit, Amsterdam, The Netherlands

    Eduard W. A. Kamperdijk  & Elisabeth C. M. Hoefsmit  & 

  2. University of Groningen, Groningen, The Netherlands

    Paul Nieuwenhuis

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© 1993 Plenum Press, New York

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Van den Eertwegh, A.J.M., Schellekens, M.M., Boersma, W.J.A., Claassen, E. (1993). Differential Uptake and Trapping of TI-2 Antigens: an Unexpected Role for Follicular Dendritic Cells in the Induction of TI-2 Immune Responses. In: Kamperdijk, E.W.A., Nieuwenhuis, P., Hoefsmit, E.C.M. (eds) Dendritic Cells in Fundamental and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 329. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-2930-9_58

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  • DOI: https://doi.org/10.1007/978-1-4615-2930-9_58

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-6272-2

  • Online ISBN: 978-1-4615-2930-9

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