Heterogeneity and Cellular Origin of Follicular Dendritic Cells

  • Yutaka Imai
  • Kunihiko Maeda
  • Mitsunori Yamakawa
  • Yasuaki Karube
  • Mikio Matsuda
  • Michio Dobashi
  • Hironobu Sato
  • Kazuo Terashima
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 329)

Abstract

Follicular dendritic cells (FDC) are specialized cells which locate within the lymphoid follicles of secondary lymphoid tissues including lymph nodes, spleen, tonsil and mucosal associate lymphoid tissues (Peyet’s patches etc). Many studies1,2,3 have been accumulated to defined the morphological, immuno-phenotypical and functional features of FDC. Nevertheless, the nature of FDC is still unsettled, especially the cellular origin, kinetics, proliferating activity, maturation processes and functional diversity. In this paper, we focused on the two major subjects, the heterogeneity and cellular origin of FDC because these are thought to be most fundamental for FDC research and summarize our recent results.

Keywords

Lymphoma Germinal Dition allO 

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Yutaka Imai
    • 1
  • Kunihiko Maeda
    • 1
  • Mitsunori Yamakawa
    • 1
  • Yasuaki Karube
    • 1
  • Mikio Matsuda
    • 1
  • Michio Dobashi
    • 1
  • Hironobu Sato
    • 1
  • Kazuo Terashima
    • 1
  1. 1.Department of PathologyYamagata university School of MedicineYamagataJapan

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