Advertisement

Dissection of Human Langerhans Cell Allostimulatory Function. Modulation by Interferon-γ.

  • J. Péguet- Navarro
  • C. Dalbiez-Gauthier
  • C. Dezutter-Dambuyant
  • D. Schmitt.
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 329)

Abstract

It has now become evident that dendritic cells (DC) are specialyzed in initiating primary T cell-dependent immune responses1. A particular large pool of DC, namely Langerhans cells (LC) are present within epidermis where they are the only cells which express MHC class II antigens constitutively. LC play a key role in the initiation of T cell responses to cutaneous antigens by picking up the antigen and migrating to the draining lymph nodes where they trigger specific T cell activation.

Keywords

Dendritic Cell Accessory Function Genzyme Corporation Allostimulatory Activity Mononuclear Cell Suspension 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    K. Inaba, R.M. Steinman, Resting and sensitized T lymphocytes exhibit distinct stimulatory (antigen-presenting cell) requirements for growth and lymphokine release, J. Exp. Med. 160: 1717 (1984).PubMedCrossRefGoogle Scholar
  2. 2.
    G. Schuler, R.M. Steinman, Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro, J. Exp. Med. 161: 526 (1985).PubMedCrossRefGoogle Scholar
  3. 3.
    N. Romani, A. Lenz, H. Glassel, H. Stossel, U. Stanzl, O. Majdic, P. Fritsch, G. Schuler, Cultured human Langerhans cells resemble lymphoid dendritic cells in phenotype and function, J. Invest. Dermatol. 93: 600 (1989).PubMedCrossRefGoogle Scholar
  4. 4.
    M.D. Witmer-Pack, W. Olivier, J. Valinsky, G. Schuler, R.M. Steinman, Granulocyte-macrophage colony-stimulating-factor is essential for the viability and function of cultured murine epidermal Langerhans cells, J. Exp. Med. 166: 1484 (1987).PubMedCrossRefGoogle Scholar
  5. 5.
    T.D. Geppert, L.S. Davis, H. Gur, M.C. Wacholtz, P.E. Lipsky, Accessory cell signals involved in T cell activation. Immunol. Rev. 117: 5 (1990).PubMedCrossRefGoogle Scholar
  6. 6.
    R.M. Steinman, The dendritic cell system and its role in immunogenicity, Annu. Rev. Immunol. 9: 271 (1991).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • J. Péguet- Navarro
    • 1
  • C. Dalbiez-Gauthier
    • 1
  • C. Dezutter-Dambuyant
    • 1
  • D. Schmitt.
    • 1
  1. 1.INSERM U346, Hôpital E. HerriotFrance

Personalised recommendations