Abstract
The aim of this study was to compare rat thymic dendritic cells in situ (i. e. interdigitating cells, IDC) with isolated dendritic cells (1) using enzyme cytochemical, immunocytochemical and electron-microscopical methods. Moreover the phenotypical and morphological changes of these isolated dendritic cells were studied after culture. To get more information about the influence of size (volume) and/or micro-environment on antigen presentation, we also compared the capacity to present GT to primed T cells by freshly isolated dendritic cells from thymus, spleen and peritoneal cavity.
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References
R. M. Steinman and Z. A. Cohn. Identification of a novel celltype in peripheral lymphoid organs of mice. J. Exp. Med. 137, 1142–1162 (1973)
D. Armerding, D. H. Katz and B. Benacerrof. Immune respons genes in inbred rats Analysis of responder status of the synthetic polypeptides and low doses of bovine serum albumin. Immunogenetics, 1 329–339 (1974)
E. W. A. Kamperdijk, M. L. Kapsenberg, M. van den Berg, and E. C. M. Hoefsmit. Characterization of dendritic cells isolated from normal and stimulated lymph nodes of the rat. Cell Tissue Res. 242 469–474 (1985)
S. C. Knight, J. Farrant, A. Bryant, A.J. Edwards, S. Burman, A. Lever, J. K. Clarke and A. D. B. Webster. Non-adherent, low density cells from human peripheral blood contain dendritic cells and monocytes, both with veiled morphology. Immunology 57, 595–603 (1986)
E. van Vugt, J. M. S. Arkema, M. A. M. Verdaasdonk, R. J. H. Beelen and E. W. A. Kamperdijk. Morphological and functional characteristics of rat steady state peritoneal dendritic cells. Immunobiol. 184 14–24 (1991)
E. W. A. Kamperdijk, M. A. M. Verdaasdonk and R. H. J. Beelen. Visual and functional expression of Ia antigens on macrophages and dendrtitic cells in ACI/Mal rats. Transplant. Proc. XIX 3024–3028 (1987)
E. W. A. Kamperdijk, E. B. J. van Nieuwkerk, J. M. S. Arkema, A. M. Duijvestijn and E. C. M. Hoefsmit. Macrophages and dendritic cells. “Accessory Cells in HIV and other Retroviral infections.” pp 136–144. Procs, Dijkstra C.D. and Gluckman J. C. (eds) Basel, Karger (1991)
A. M. Duijvestijn, Y. G. Köhler and E. C. M. Hoefsmit. Interdigitating cells and macrophages in the acute involuting rat thymus. An electronmicroscopic study on phagocytic activity on population development. Cell Tissue Res. 224 291–301 (1982)
E. W. A. Kamperdijk, E. B. J. van Nieuwkerk, M. A. M. Verdaasdonk and E. C. M. Hoefsmit. Macrophages in different compartments of the non-neoplastic lymph node. Curr. Topics in Path. 84 219–245 (1990)
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© 1993 Plenum Press, New York
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Kamperdijk, E.W.A., Arkema, J.M.S., Verdaasdonk, M.A.M., Beelen, R.H.J., van Vugt, E. (1993). Rat Thymic Dendritic Cells. In: Kamperdijk, E.W.A., Nieuwenhuis, P., Hoefsmit, E.C.M. (eds) Dendritic Cells in Fundamental and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 329. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-2930-9_24
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DOI: https://doi.org/10.1007/978-1-4615-2930-9_24
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