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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 329))

Abstract

The specific activation of a T lymphocyte depends on the interaction of its T cell receptor with the antigenic peptide - MHC complex on the surface of an antigen presenting cells (APC). In order for full primary T cell activation to occur the APC must provide essential additional co-stimulatory activity. 1 The ability to provide this “second signal” is a distinguishing feature of the specialist APC known as dendritic cells (DC) but the exact nature of this cellular property remains uncertain.2

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References

  1. D. L. Mueller, M. K. Jenkins, and R. H. Schwartz, Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy, Ann. Rev. Immunol. 7: 445 (1989).

    Article  CAS  Google Scholar 

  2. R. M. Steinman and M. C. Nussenweig, Dendritic cells: features and functions, Immunol. Rev. 53: 127 (1989).

    Article  Google Scholar 

  3. J. L. McKenzie, T. C. R. Prickett and D. N. J. Hart, Human dendritic cells stimulate allogeneic T cells in the absence of interleukin 1, Immunology. 67: 290 (1989).

    CAS  PubMed  PubMed Central  Google Scholar 

  4. D. N. J. Hart and J. L. McKenzie, Isolation and characterisation of human tonsil dendritic cells, J. Exp. Med. 168: 157 (1988).

    Article  CAS  Google Scholar 

  5. T. A. Springer, Adhesion receptors of the immune system, Nature, 346: 425 (1990).

    Article  CAS  Google Scholar 

  6. T. C. R. Prickett, J. L. McKenzie and D. N. J. Hart, Adhesion molecules on human tonsil dendritic cells, Transplantation, 53: 4831 (1992).

    Article  Google Scholar 

  7. A. R. Fougerolles and T. A. Springer, Intercellular adhesion molecule 3, a third adhesion counter-receptor for lymphocyte function — associated molecule 1 on resting lymphocytes, J. Exp. Med. 175: 185 (1992).

    Article  Google Scholar 

  8. Y. J. Rosenstein, J. K. Park, W. C. Hahn, F. S. Rosen, B. E. Bierer and S. J. Burakoff, CD43-a molecule defective in Wiskott-Aldrich syndrome binds ICAM-1, Nature. 354: 233 (1991).

    Article  CAS  Google Scholar 

  9. M. Brenan and M. Puklavec, The MRC OX-62 antigen: a useful marker in the purification of rat veiled cells with the biochemical properties of an integrin, J. Exp. Med. 175: 1457 (1992).

    Article  CAS  Google Scholar 

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© 1993 Plenum Press, New York

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Hart, D.N.J., Prickett, T.C.R. (1993). Adhesion Molecules in Tonsil DC-T Cell Interactions. In: Kamperdijk, E.W.A., Nieuwenhuis, P., Hoefsmit, E.C.M. (eds) Dendritic Cells in Fundamental and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 329. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-2930-9_11

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  • DOI: https://doi.org/10.1007/978-1-4615-2930-9_11

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-6272-2

  • Online ISBN: 978-1-4615-2930-9

  • eBook Packages: Springer Book Archive

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