Transcriptional Activation by the Hepatitis B Virus X Protein
Human HBV is a member of a family of hepatotropic viruses with double-stranded DNA genomes (Robinson et al., 1982), which include woodchuck hepatitis virus (WHV, Summers et al., 1978), ground squirrel hepatitis virus (GSHV, Lee et al., 1988), and duck hepatitis virus (DHBV, Mason et al., 1980). All members maintain persistent infections, but the human and woodchuck viruses appear to cause the most significant chronic active infection and hepatocellular carcinoma (HCC, reviewed in Ganem and Varmus, 1987; Tiollais et al., 1985). The correlation between chronic HBV infection and development of HCC has been well established, primarily from epidemiological and clinical evidence (Beasley et al., 1981; Szumness, 1978; reviewed in Ganem and Varmus, 1987; Popper et al., 1987).
KeywordsChloramphenicol Acetyl Transferase Chloramphenicol Acetyl Transferase Activation SV40 Enhancer Duck Hepatitis Virus Chloramphenicol Acetyl Transferase Assay
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