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Glucocorticoid Receptors in Leukemias, Lymphomas and Myelomas of Young and Old

  • Chapter
The Underlying Molecular, Cellular and Immunological Factors in Cancer and Aging

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 330))

Abstract

Glucocorticoids are well-known for their strong suppressive influence on certain cells of the immune system. These pharmacologic effects have long been taken advantage of to suppress immune responses and to treat leukemia and lymphomas. In recent years, a great deal has been learned of the mechanisms by which glucocorticoids affect lymphoid and related cells, and this information now provides a basis for studying the varying susceptibility to glucocorticoid therapy of the leukemias, lymphomas and myelomas in young and older patients. Expression of glucocorticoid receptors themselves is sometimes used as one predictive variable (Bloomfield, 1984; Thompson et al., 1985; Iacobelli et al., 1987). In this brief overview, we will outline the general pattern of expression with age of these groups of malignancies, discuss the recently established principles of glucocorticoid action, and describe some of our own experience with glucocorticoid effects on certain malignant lymphoid cell lines in vitro.

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  1. Department of Human Biological Genetics and Chemistry, University of Texas Medical Branch, Galveston, Texas, 77550, USA

    Javed Ashraf & E. Brad Thompson

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  1. Javed Ashraf
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  1. National Cancer Institute, Bethesda, Maryland, USA

    Stringner Sue Yang Ph.D.

  2. National Institute on Aging, Bethesda, Maryland, USA

    Huber R. Warner Ph.D.

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Ashraf, J., Thompson, E.B. (1993). Glucocorticoid Receptors in Leukemias, Lymphomas and Myelomas of Young and Old. In: Yang, S.S., Warner, H.R. (eds) The Underlying Molecular, Cellular and Immunological Factors in Cancer and Aging. Advances in Experimental Medicine and Biology, vol 330. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2926-2_18

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