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Non-Invasive Measurements of the Cerebral Steady-State Glucose Concentration and Transport in Humans by 13C Nuclear Magnetic Resonance

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Frontiers in Cerebral Vascular Biology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 331))

Abstract

Glucose transport across the blood-brain barrier (BBB) has been shown to be a carrier-mediated, saturable process of the facilitated diffusion type (4). The cerebral steady-state glucose concentration depends on the kinetic properties of transport and is lower than in blood. Direct measurement of brain glucose is not possible in humans by non-invasive techniques using radioactive tracers because the signal of labeled glucose cannot be distinguished from that of its metabolic products.

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Author notes

  1. Rolf Gruetter

    Present address: Magnetic Resonance Center, Inselspital and University, Inselheimmatte, CH-3010, Bern, Switzerland

Authors and Affiliations

  1. Department of Molecular Biology and Biochemistry, Yale University, New Haven, CT, 06510, USA

    Rolf Gruetter, Graeme F. Mason & Robert G. Shulman

  2. Department of Pediatrics and Neurology, New Haven, CT, 06510, USA

    Edward J. Novotny, Susan D. Boulware & William V. Tamborlane

  3. Department of Internal Medicine, Yale School of Medicine, Yale University, New Haven, CT, 06510, USA

    Douglas L. Rothman & Gerald I. Shulman

Authors
  1. Rolf Gruetter
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  2. Edward J. Novotny
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  3. Susan D. Boulware
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  4. Douglas L. Rothman
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  5. Graeme F. Mason
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  6. Gerald I. Shulman
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  7. William V. Tamborlane
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  8. Robert G. Shulman
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Editor information

Editors and Affiliations

  1. University of Minnesota, Duluth, Minnesota, USA

    Lester R. Drewes

  2. The University of Michigan, Ann Arbor, Michigan, USA

    A. Lorris Betz

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© 1993 Springer Science+Business Media New York

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Gruetter, R. et al. (1993). Non-Invasive Measurements of the Cerebral Steady-State Glucose Concentration and Transport in Humans by 13C Nuclear Magnetic Resonance. In: Drewes, L.R., Betz, A.L. (eds) Frontiers in Cerebral Vascular Biology. Advances in Experimental Medicine and Biology, vol 331. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2920-0_7

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  • DOI: https://doi.org/10.1007/978-1-4615-2920-0_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6267-8

  • Online ISBN: 978-1-4615-2920-0

  • eBook Packages: Springer Book Archive

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