Cerebral Endothelial Mechanisms in Increased Permeability in Chronic Hypertension

  • Sukriti Nag
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 331)


Our previous studies (4, 5) demonstrated that increased cerebrovascular permeability to protein in acute hypertension was associated with reduced activity of the endothelial plasma membrane adenosine triphosphatases (ATPases). This study was undertaken to determine when during the course of chronic hypertension a change in the activity of the plasma membrane calcium-activated ATPase (Ca2+-ATPase) and the ouabain-sensitive, K+ dependent p-nitrophenylphosphatase (Na+, K+ATPase) occurs.


Chronic Hypertension Adenosine Triphosphatases Outer Plasma Membrane Calcium Entry Blocker Pinocytotic Vesicle 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Sukriti Nag
    • 1
  1. 1.Department of PathologyQueen’s UniversityKingstonCanada

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