Cerebral Endothelial Mechanisms in Increased Permeability in Chronic Hypertension
Our previous studies (4, 5) demonstrated that increased cerebrovascular permeability to protein in acute hypertension was associated with reduced activity of the endothelial plasma membrane adenosine triphosphatases (ATPases). This study was undertaken to determine when during the course of chronic hypertension a change in the activity of the plasma membrane calcium-activated ATPase (Ca2+-ATPase) and the ouabain-sensitive, K+ dependent p-nitrophenylphosphatase (Na+, K+ATPase) occurs.
KeywordsPermeability Citrate Adenosine Flunarizine
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