Mathematical Models of Lesion Induction and Repair in Irradiated Cells
The interaction of ionizing radiation with biological objects gives rise to two opposite processes. The first one comprises the destructive action of radiation on biologically important molecules, with the formation of radicals, their interaction and the fixation of biologically significant damage. The second one concerns the elimination of these injuries by biological processes accompanied by fixation of final molecular changes and their macroscopic manifestation. The kinetics of these two processes are quite different. Physical and chemical reactions are terminated within the first milliseconds, whereas early steps of the cellular repair run at least in the range of seconds. DNA strand breaks will be considered as biologically significant lesions that can be defined and detected.
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