The Intermediate Compartment between Endoplasmic Reticulum and Golgi Complex in Mammalian Cells
Several lines of evidence strongly support the view that the traffic between ER and Golgi complex involves one (or more) previously unidentified membranous structure. This fascinating new finding is based on data obtained in several different experimental systems with different methodology. Unavoidably, many terms have been suggested for this structure: pre-Golgi vacuoles (Saraste and Kuismanen, 1984), budding compartment (Tooze et al., 1988), intermediate compartment (Schweizer et al., 1990), intermediate elements (Saraste and Svensson, 1991), salvage compartment (Munro and Pelham, 1987), cis-Golgi network (Mellman and Simons, 1992). Throughout this review, we will use only the term “intermediate compartment.” Many different findings and opinions on the structure and function of the intermediate compartment have been reported and will be considered throughout this review: thus, we will present our own view from the beginning, to give the readers a guideline in this intricate pathway.
KeywordsEndoplasmic Reticulum Golgi Complex Rubella Virus Exit Site Rab2 Protein
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