The Intermediate Compartment between Endoplasmic Reticulum and Golgi Complex in Mammalian Cells

  • Stefano Bonatti
  • Maria Rosaria Torrisi
Part of the Subcellular Biochemistry book series (SCBI, volume 21)


Several lines of evidence strongly support the view that the traffic between ER and Golgi complex involves one (or more) previously unidentified membranous structure. This fascinating new finding is based on data obtained in several different experimental systems with different methodology. Unavoidably, many terms have been suggested for this structure: pre-Golgi vacuoles (Saraste and Kuismanen, 1984), budding compartment (Tooze et al., 1988), intermediate compartment (Schweizer et al., 1990), intermediate elements (Saraste and Svensson, 1991), salvage compartment (Munro and Pelham, 1987), cis-Golgi network (Mellman and Simons, 1992). Throughout this review, we will use only the term “intermediate compartment.” Many different findings and opinions on the structure and function of the intermediate compartment have been reported and will be considered throughout this review: thus, we will present our own view from the beginning, to give the readers a guideline in this intricate pathway.


Endoplasmic Reticulum Golgi Complex Rubella Virus Exit Site Rab2 Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Stefano Bonatti
    • 1
  • Maria Rosaria Torrisi
    • 2
  1. 1.Department of Biochemistry and Medical BiotechnologyUniversity of Naples “Federico II,”NaplesItaly
  2. 2.Department of Experimental MedicineUniversity of Rome “La Sapienza,”RomeItaly

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