The Role of Alcohol and Aldehyde Dehydrogenases In Alcohol-Related Diseases: Clinical Studies of Molecular Markers
The rapid advances achieved in the field of molecular genetics over the past few years have had a profound effect on the study of complex conditions as well as single gene disorders. In the field of alcoholism and alcohol - related diseases, the application of these new techniques is now gathering pace. There is general agreement that a significant genetic component exists in alcoholism, as illustrated by the twin and adoption studies performed over the past 20 years, but this clearly does not conform to a simple Mendelian model. The central question that is being addressed concerns the inherited basis for the observed variation in individual responses to ethanol.
KeywordsAldehyde Dehydrogenase Alcoholic Hepatitis ALDHI Activity ALDH2 Gene Alcohol Related Disorder
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