The Role of Alcohol and Aldehyde Dehydrogenases In Alcohol-Related Diseases: Clinical Studies of Molecular Markers

  • David I. N. Sherman
  • Roberta J. Ward
  • Timothy J. Peters
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 328)


The rapid advances achieved in the field of molecular genetics over the past few years have had a profound effect on the study of complex conditions as well as single gene disorders. In the field of alcoholism and alcohol - related diseases, the application of these new techniques is now gathering pace. There is general agreement that a significant genetic component exists in alcoholism, as illustrated by the twin and adoption studies performed over the past 20 years, but this clearly does not conform to a simple Mendelian model. The central question that is being addressed concerns the inherited basis for the observed variation in individual responses to ethanol.


Aldehyde Dehydrogenase Alcoholic Hepatitis ALDHI Activity ALDH2 Gene Alcohol Related Disorder 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • David I. N. Sherman
    • 1
  • Roberta J. Ward
    • 1
  • Timothy J. Peters
    • 1
  1. 1.Department of Clinical BiochemistryKings College School of Medicine and DentistryLondonUK

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