Effects of Aldehyde Products of Lipid Peroxidation on the Activity of Aldehyde Metabolizing Enzymes in Hepatomas
In general, lipid peroxidation in hepatomas and hepatoma cell lines is lower than in normal tissue (Dianzani et al., 1986; Poli et al., 1986). It is known that lipid peroxidation, which often occurs in response to oxidative stress, produces a great diversity of aldehydes, when lipid hydroperoxides break down in biological systems. Some of these aldehydes are highly reactive, and may be considered as second toxic messengers, which disseminate and augment initial free radical events. The aldehydes most intensively studied are 4-hydroxynonenal (4-HNE), 4-hydroxyhexenal, and malondialdehyde (Esterbauer et al., 1988). 4-HNE has been demonstrated to inhibit various biochemical processes in liver and tumour cells (Canuto et al., 1985).
KeywordsLipid Peroxidation Arachidonic Acid Hepatoma Cell Hepatoma Cell Line ALDH Activity
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