Effects of Aldehyde Products of Lipid Peroxidation on the Activity of Aldehyde Metabolizing Enzymes in Hepatomas

  • Rosa A. Canuto
  • Margherita Ferro
  • Giuliana Muzio
  • Anna M. Bassi
  • Gabriella Leonarduzzi
  • Marina Maggiora
  • Daniela Adamo
  • Giuseppe Poli
  • Ronald Lindahl
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 328)

Abstract

In general, lipid peroxidation in hepatomas and hepatoma cell lines is lower than in normal tissue (Dianzani et al., 1986; Poli et al., 1986). It is known that lipid peroxidation, which often occurs in response to oxidative stress, produces a great diversity of aldehydes, when lipid hydroperoxides break down in biological systems. Some of these aldehydes are highly reactive, and may be considered as second toxic messengers, which disseminate and augment initial free radical events. The aldehydes most intensively studied are 4-hydroxynonenal (4-HNE), 4-hydroxyhexenal, and malondialdehyde (Esterbauer et al., 1988). 4-HNE has been demonstrated to inhibit various biochemical processes in liver and tumour cells (Canuto et al., 1985).

Keywords

Respiration Aldehyde Trypsin Cytosol Malondialdehyde 

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References

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Rosa A. Canuto
    • 2
  • Margherita Ferro
    • 1
  • Giuliana Muzio
    • 2
  • Anna M. Bassi
    • 1
  • Gabriella Leonarduzzi
    • 2
  • Marina Maggiora
    • 2
  • Daniela Adamo
    • 1
  • Giuseppe Poli
    • 2
  • Ronald Lindahl
    • 3
  1. 1.Institute of General PathologyUniversity of GenoaItaly
  2. 2.Dept. Experimental Oncology and MedicineUniversity of TurinTurinItaly
  3. 3.Dept. Biochemistry and Molecular BiologyUniversity of South DakotaVermillionUSA

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